Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2005-07-26
2005-07-26
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S254200
Reexamination Certificate
active
06921666
ABSTRACT:
Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable by restoring the mismatch repair system to proper functionality.
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Grasso Luigi
Kinzler Kenneth W.
Nicolaides Nicholas C.
Sass Philip M.
Vogelstein Bert
Banner & Witcoff , Ltd.
Ketter James
Morphotek
The Johns Hopkins University
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