Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-04-11
2006-04-11
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S471000, C435S252100
Reexamination Certificate
active
07026119
ABSTRACT:
Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.
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Grasso Luigi
Kinzler Kenneth W.
Nicolaides Nicholas C.
Sass Philip M.
Vogelstein Bert
Akhavan Ramin (Ray)
Banner & Witcoff , Ltd.
Guzo David
Morphotek Inc.
The Johns Hopkins University
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