Methods for generating cytotoxic T cells and treatment of diseas

Details Methods for generating cytotoxic T cells and treatment of diseas Methods for generating cytotoxic T cells and treatment of diseas

1995-05-16

2000-03-07

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424 9371, 4242771, 4242651, 4241841, 435 691, 530350, 530300, 530402, 536 2372, 514 8, A61K 39385, A61K 4505

Patent

active

060336692

ABSTRACT:
The present invention relates a novel class of biologically active compounds, to processes for their production and to their use in therapy. More particularly the invention provides immunogenic conjugates useful for generating T cell immunity against tumor-associated carbohydrate structures or against carbohydrate structures expressed on infectious agents and/or infected host cells. The said immunogenic conjugate comprises,(i) a peptide component capable of binding a MHC class I molecule; and (ii) a carbohydrate component having the immunogenic specificity of said carbohydrate structure.

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