Methods for functionalizing and coating substrates and devices m

Coating processes – Direct application of electrical – magnetic – wave – or... – Pretreatment of substrate or post-treatment of coated substrate

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

427 213, 427 224, 427387, 4273881, 427552, 427596, 427337, B05D 714, B05D 306, B05D 310

Patent

active

058305394

ABSTRACT:
Methods for coating substrates are described. The methods comprise coating at least a portion of a substrate with particular coating materials. The coating materials can be crosslinked and coated onto a substrate. Alternatively, the coating materials may be covalently bonded to the substrates. The coating materials might themselves functionalize the substrate, or provide a biocompatible coating on the substrate. The coating materials might also include electrophilic or nucleophilic groups that allow for the subsequent reaction of the coating materials with additional reagents. The present invention also provides coated workpieces, particularly medical workpieces having a surface for contacting tissue or blood. These workpieces comprise a first layer and a second layer. The first layer comprises a molecular tether covalently bonded to the surface. The second layer is bonded to the article by the first layer and comprises a bioactive agent selected from the group consisting of biocompatible polymers, antibiotics, antimicrobials and anticoagulants.

REFERENCES:
patent: 3205206 (1965-09-01), Marcantonio
patent: 3211713 (1965-10-01), Breslow
patent: 3284421 (1966-11-01), Breslow
patent: 3888833 (1975-06-01), Lednicer et al.
patent: 4007089 (1977-02-01), Smith, III
patent: 4309453 (1982-01-01), Reiner et al.
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4654292 (1987-03-01), Oie et al.
patent: 4716122 (1987-12-01), Scheefers
patent: 4767814 (1988-08-01), Bae et al.
patent: 4798585 (1989-01-01), Inoue et al.
patent: 4835258 (1989-05-01), Hollenberg et al.
patent: 4898951 (1990-02-01), Symons
patent: 5002582 (1991-03-01), Guire et al.
patent: 5024742 (1991-06-01), Nesburn et al.
patent: 5240747 (1993-08-01), Matsuda et al.
patent: 5336518 (1994-08-01), Narayanan et al.
patent: 5344455 (1994-09-01), Keogh et al.
patent: 5372888 (1994-12-01), Ogawa et al.
patent: 5405766 (1995-04-01), Kallury et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5547711 (1996-08-01), Kirchmayer et al.
patent: 5580697 (1996-12-01), Keana et al.
Y. Imanishi, "Polymeric Biomaterials," Materials Science and Engineering, C1, pp. 143-147 (1994)(no month available).
Ishihara, et al., "Designing Biocompatible Materials," Chemtech, pp. 19-25 (Oct. 1993).
D. Williams, "Advanced Applications for Materials Implanted Within the Human Body," Materials Science and Technology, vol. 3, pp. 797-806 (Oct. 1987).
Legeay, et al., "Surface Treatment and Biomaterial," Le Vide, les Couches Minces No. 267--Mai-Juin-Juillet, pp. 161-170 (1993).
"A Coat of Many Lipids--In the Clinic," Chemistry in Britain, pp. 253-257 (Mar. 1992).
Eberhart, et al., "Platelets, Catheters, and the Vessel Wall--Catheter Coatings, Blood Flow, and Biocompatibility," Seminars in Hematology, vol. 28, No. 4, Suppl. 7, pp. 42-48 (Oct. 1991).
D. Chapman, "Biocompatible Surfaces Based Upon the Phospholipid Asymmetry of Biomembranes," Biochemical Society Transactions, pp. 258-262 1993 (no month available).
Sanchez, et al., "Synthesis of Hemocompatible Materials. Part 1: Surface Modification of Polyurethanes Based on Poly (chloroalkylvinylether) s by RGD Fragments," Clinical Materials 15, pp. 253-258 (1994). no month available.
Moussy, et al., "Prevention of the Rapid Degradation of Subcutganeously Implanted Ag/AgC1 Reference Electrodes Using Polymer Coatings," Anal. Chem., v.66, pp. 674-679 (1994) Mar.
Osteraass, et al., "Modification of Polyethylene Surfaces with Carbethoxy Substituted Carbenes and Nitrenes,," J. Appl. Polym. Sci., 13:1537-1544 (1969)(no month available).
Osteraas, et al., "Incorporation of Functional Groups Onto the Surface of Polyethylene," Nature, 221:1140-1141 (1969) Mar.
Abbott, et al., "Manipulation of the Wettability of Surfaces on the 0.1- to 1-Micrometer Scale Through Micromachining and Molecular Self-Assembly," Science, 257:1380-1381(1992) Sep.
Stenger, et al., "Coplanar Molecular Assemblies of Amino and Perfluorinated Alkylsilanes: Characterization and Geometric Definition of Mammalian Cell Adhesion and Browth," J. Am. Chem. Soc., 114:8435-8442 (1992)(no month).
Wring, et al., "Chemically Modified, Carbon-based Electrodes and Their Application as Electrochemical Sensors for the Analysis of Biologically Important Compounds--A Review," Analyst, 117:1215-1229 (1992) Aug.
Yokohama, et al., "Synthesis of Poly (ethylene oxide) with Heterobifunctional Reactive Groups at Its Terminals by an Anionic Initiator," Bioconjugate Chem., 3:275-276 (1992) no month.
Braybrook, et al., "Organic Polymer Surfaces for Use in Medicine: Their Formation, Modification, Characterisation and Application," Prog. Polym. Sci., 15:715-734 (1990) no month.
Carlsson, et al., "Plasma Modification and Its Effect on Polymer-Polymer and Polymer-Metal Adhesion," Polymer Materials Science and Engineering, Fall Meeting 1992, Washington, D.C. vol. 67, pp. 21-23 (1992) (no month available).
Cai, et al., "Introduction of Functional Groups into Polymer Films via Deep-UV Photolysis of Electron-Beam Lithography: Modification of Ploystyrene and Poly (3-octylthiophene) by a Fucntionalized Perfluorophenyl Azide," Chem. Mater.,4:879-884 (1992)(no month available).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for functionalizing and coating substrates and devices m does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for functionalizing and coating substrates and devices m, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for functionalizing and coating substrates and devices m will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-687114

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.