Organic compounds -- part of the class 532-570 series – Organic compounds – Rare earth containing
Reexamination Certificate
2005-02-08
2005-02-08
Jones, Dameron Levest (Department: 1616)
Organic compounds -- part of the class 532-570 series
Organic compounds
Rare earth containing
C424S001110, C424S009100, C424S009360
Reexamination Certificate
active
06852842
ABSTRACT:
Small dendrimer-based MRI contrast agents are disclosed to accumulate in renal tubules. The accumulation enables visualization of renal structure and function, permitting assessment of structural and functional damage to the kidneys. In a disclosed embodiment, six, small dendrimer-based MRI contrast agents were synthesized, and their pharmacokinetics, whole body retention, and renal MRI images were evaluated in mice. Surprisingly, despite having unequal renal clearance properties, all of the dendrimer agents clearly visualized the renal anatomy and proximal straight tubules of the mice better than Gd-[DTPA]-dimeglumine. Dendrimer conjugate contrast agents prepared from PAMAM-G2D, DAB-G3D, and DAB-G2D dendrimers were excreted rapidly and may be acceptable for use in clinical applications.
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Brechbiel Martin W.
Kobayashi Hisataka
Star Robert A.
Jones Dameron Levest
Klarquist & Sparkman, LLP
The United States of America as represented by the Secretary of
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