Methods for fabrication, uses and compositions of small...

Details Methods for fabrication, uses and compositions of small... Methods for fabrication, uses and compositions of small...

2004-07-19

2011-12-13

Tran, S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S490000

Reexamination Certificate

active

08075919

ABSTRACT:
The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 μm to about 200 μm.

REFERENCES:
patent: 3102077 (1963-08-01), Christensen
patent: 3737337 (1973-06-01), Schnoring et al.
patent: 3891570 (1975-06-01), Fukushima et al.
patent: 4389330 (1983-06-01), Tice et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4652441 (1987-03-01), Okada et al.
patent: 4728721 (1988-03-01), Yamamoto et al.
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4849228 (1989-07-01), Yamamoto et al.
patent: 4853462 (1989-08-01), Hostetler et al.
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4897268 (1990-01-01), Tice et al.
patent: 4904479 (1990-02-01), Illum
patent: 4917893 (1990-04-01), Okada et al.
patent: 5066436 (1991-11-01), Komen et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5102872 (1992-04-01), Singh et al.
patent: 5149543 (1992-09-01), Cohen et al.
patent: 5213812 (1993-05-01), Ruiz
patent: 5300464 (1994-04-01), Rittler
patent: 5330767 (1994-07-01), Yamamoto et al.
patent: 5330768 (1994-07-01), Park et al.
patent: 5360610 (1994-11-01), Tice et al.
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5407609 (1995-04-01), Tice et al.
patent: 5417986 (1995-05-01), Reid et al.
patent: 5422120 (1995-06-01), Kim
patent: 5476663 (1995-12-01), Okada et al.
patent: 5480656 (1996-01-01), Okada et al.
patent: 5482927 (1996-01-01), Maniar et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5556642 (1996-09-01), Kobayashi et al.
patent: 5575987 (1996-11-01), Kamei et al.
patent: 5578709 (1996-11-01), Woiszwillo
patent: 5599719 (1997-02-01), Woiszwillo
patent: 5603961 (1997-02-01), Suzuki et al.
patent: 5631020 (1997-05-01), Okada et al.
patent: 5631021 (1997-05-01), Okada et al.
patent: 5643607 (1997-07-01), Okada et al.
patent: 5650173 (1997-07-01), Ramstack et al.
patent: 5654008 (1997-08-01), Herbert et al.
patent: 5654010 (1997-08-01), Johnson et al.
patent: 5665428 (1997-09-01), Cha et al.
patent: 5667808 (1997-09-01), Johnson et al.
patent: 5716640 (1998-02-01), Kamei et al.
patent: 5851451 (1998-12-01), Takechi et al.
patent: 5891478 (1999-04-01), Johnson et al.
patent: 5932248 (1999-08-01), Chen et al.
patent: 5945126 (1999-08-01), Thanoo et al.
patent: 5981719 (1999-11-01), Woiszwillo et al.
patent: 5989463 (1999-11-01), Tracy et al.
patent: 6036976 (2000-03-01), Takechi et al.
patent: 6042792 (2000-03-01), Shefer et al.
patent: 6051259 (2000-04-01), Johnson et al.
patent: 6063910 (2000-05-01), Debenedetti et al.
patent: 6090925 (2000-07-01), Woiszwillo et al.
patent: 6120787 (2000-09-01), Gustafsson et al.
patent: 6153211 (2000-11-01), Hubbell et al.
patent: 6268053 (2001-07-01), Woiszwillo et al.
patent: 6270795 (2001-08-01), Jones et al.
patent: 6270802 (2001-08-01), Thanoo et al.
patent: 6361798 (2002-03-01), Thanoo et al.
patent: 6395253 (2002-05-01), Levy et al.
patent: 6395302 (2002-05-01), Hennink et al.
patent: 6455074 (2002-09-01), Tracy et al.
patent: RE37872 (2002-10-01), Franks et al.
patent: 6458387 (2002-10-01), Scott et al.
patent: 6500448 (2002-12-01), Johnson et al.
patent: 6506410 (2003-01-01), Park et al.
patent: 6596316 (2003-07-01), Lyons et al.
patent: 6616949 (2003-09-01), Jonsson et al.
patent: RE38385 (2004-01-01), Hatley et al.
patent: 6749866 (2004-06-01), Bernstein et al.
patent: 6830737 (2004-12-01), Ramstack
patent: 6861064 (2005-03-01), Laakso et al.
patent: 2001/0002261 (2001-05-01), Morrison et al.
patent: 2003/0007990 (2003-01-01), Blankenship et al.
patent: 2003/0059474 (2003-03-01), Scott et al.
patent: 2003/0064033 (2003-04-01), Brown et al.
patent: 2003/0211153 (2003-11-01), Johnson et al.
patent: 2004/0039171 (2004-02-01), Matsumoto et al.
patent: 2004/0043076 (2004-03-01), Dulieu et al.
patent: 2005/0142201 (2005-06-01), Rashba-Step et al.
patent: 2005/0142205 (2005-06-01), Rashba-Step et al.
patent: 2005/0147687 (2005-07-01), Rashba-Step et al.
patent: 2005/0170005 (2005-08-01), Rashba-Step et al.
patent: 2005/0233945 (2005-10-01), Brown et al.
patent: 2006/0024379 (2006-02-01), Brown et al.
patent: 2007/0092452 (2007-04-01), Rashba-Step et al.
patent: 2008/0026068 (2008-01-01), Brown et al.
patent: 2157793 (1994-09-01), None
patent: 248531 (1986-01-01), None
patent: 0377477 (1990-07-01), None
patent: 809110 (1997-11-01), None
patent: 1060741 (2000-12-01), None
patent: 11-302156 (1999-11-01), None
patent: 2147226 (2000-04-01), None
patent: WO-93/14110 (1993-07-01), None
patent: WO 94/20856 (1994-09-01), None
patent: WO 9420856 (1994-09-01), None
patent: WO9500128 (1995-01-01), None
patent: WO-96/09814 (1996-04-01), None
patent: WO-96/38153 (1996-12-01), None
patent: WO-99/55310 (1999-11-01), None
patent: WO-00/00176 (2000-01-01), None
patent: WO-02/39985 (2002-05-01), None
patent: WO-02/43580 (2002-06-01), None
patent: WO-02/055059 (2002-07-01), None
patent: WO 03/000014 (2003-01-01), None
patent: WO-03/015750 (2003-02-01), None
patent: WO 03015750 (2003-02-01), None
US 5,849,884, 12/1998, Woiszwillo et al. (withdrawn)
“Yang, et al., Crystalline monoclonal antibodies for subcutaneous delivery, Proc. Natl. Acad. Sci (USA), Jun. 10, 2003, vol. 100, No. 12, pp. 6934-6939.”
Supplementary European Search Report for European patent application 04809503. dated Aug. 22, 2007.
Van Der Lubben et al., “Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice,”Vaccine,21:1400-1408 (2003).
Brazeau et al., “In vitro myotoxicity of selected cationic macromolecules used in non-viral gene delivery”, 1998, Pharmaceutical Research, vol. 15(5), pp. 680-684.
Brown et al., “Pulmonary Delivery of Novel Insulin Microspheres”, 2002, Proceed, Respiratory Drug Delivery VIII, DHI Publishing, Raleigh, N. C., 431-434.
Brown et al., “PROMAXX Microsphere Characterization”, 2004, Proceed. Of Resp. Drug. Del. IX, pp. 477-479.
Bustami et al., “Generation of Micro-Particles of Proteins for Aerosol Delivery Using High Pressure Modified Carbon Dioxide”, 2000, Pharmaceutical Research, vol. 17, pp. 1360-1366.
Chu et al., “Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture”, 1990, Pharmaceutical Research, vol. 7, pp. 824-834.
Moghimi, “Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers”, 2002, Biochimica et Biophysica Acta, vol. 1590, pp. 131-139.
Morita et al., “Formation and Isolation of Spherical Fine Protein Microparticles Through Lyophilization of Protein-Poly (ethylene Glycol) Aqueous Mixture”, 2000, Pharmaceutical Research, vol. 17(11), pp. 1367-1373.
Rashba-Step et al., “Albumin Microspheres as Drug Delivery Vehicle for Multiple Routes of Administration”, 2001, Proceed. Int'l. Symp. Control. Rel. Bioact. Material, vol. 28, pp. 1001-1002.
Sah et al., “Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release”, Journal of Microencapsulation, 1995, vol. 12(1), pp. 59-69.
Sinha et al., “Biodegradable microspheres for protein delivery”, 2003, Journal of Controlled Release, vol. 90, pp. 261-280.
Vanderkerken et al., Synthesis and evaluation of poly(ethylene glycol)-polylysine block copolymers as carriers for gene delivery, 2000, Journal of Bioactive and Compatible Polymers, vol. 15(2), pp. 115-138.
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