Methods for fabricating polymer-based controlled release devices

Details Methods for fabricating polymer-based controlled release devices Methods for fabricating polymer-based controlled release devices

1997-09-24

1999-11-23

Nutter, Nathan M.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

6048901, 424484, 424486, 424489, 514 2, 514 21, B01J 1302, B01J 1304, A61K 922

Patent

active

059894636

ABSTRACT:
The present invention relates to a polymer-based sustained release device, and methods of forming and using the device for the sustained release of an active agent. The improved method of the invention for forming a polymer-bases sustained release device comprises forming a polymer/active agent solution by mixing a polymer, a continuous phase, and an active agent. The continuous phase can comprise one or more polymer solvents, a polymer solvent/polymer non-solvent mixture, or a polymer solvent/active agent non-solvent mixture. When the continuous phase comprises a polymer solvent/active agent non-solvent, the active agent can also be present as a microparticulate rather than in solution. The continuous phase is then removed from the polymer/active agent solution, thereby forming a solid polymer/active agent matrix.

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