Methods for extending the replicative lifespan of cells

Details Methods for extending the replicative lifespan of cells Methods for extending the replicative lifespan of cells

2006-06-14

2010-11-23

McGarry, Sean R (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S375000, C435S377000, C435S006120, C536S023100, C536S024100, C536S024500

Reexamination Certificate

active

07838503

ABSTRACT:
The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence of a SIRT1 inhibitor. The resulting cultured cells can be used for a variety of applications including cell-based therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.

REFERENCES:
patent: 4690915 (1987-09-01), Rosenberg
patent: 5126132 (1992-06-01), Rosenberg
patent: 5443983 (1995-08-01), Ochoa et al.
patent: 5766920 (1998-06-01), Babbitt et al.
patent: 5846827 (1998-12-01), Celis et al.
patent: 6040177 (2000-03-01), Riddell et al.
patent: 6194207 (2001-02-01), Bell et al.
patent: 6204058 (2001-03-01), Bolton
patent: 6210662 (2001-04-01), Laus et al.
patent: 6210963 (2001-04-01), Haddada et al.
patent: 6225044 (2001-05-01), Klein et al.
patent: 6227368 (2001-05-01), True
patent: 6251385 (2001-06-01), Terman
patent: 6255073 (2001-07-01), Cai et al.
patent: 6787300 (2004-09-01), Guarente et al.
patent: 2001/0026930 (2001-10-01), Guarente et al.
patent: 2003/0082597 (2003-05-01), Cannon et al.
patent: 2003/0124101 (2003-07-01), Gu et al.
patent: 2003/0157711 (2003-08-01), Oh
patent: 2003/0175242 (2003-09-01), Gruenberg
patent: 2003/0185790 (2003-10-01), Bauer et al.
patent: 2003/0207325 (2003-11-01), Guarente et al.
patent: 2004/0005574 (2004-01-01), Guarente et al.
patent: 2004/0028607 (2004-02-01), Verdin et al.
patent: 2004/0067228 (2004-04-01), Denu et al.
patent: 2004/0091953 (2004-05-01), Verdin et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0019865 (2005-01-01), Kihm et al.
patent: WO2006006171 (2006-01-01), None
Milligan et al., Journal of Medicinal Chemistry vol. 36(14):1923-1937, 1993.
Iwama et al., “Enhanced Self-Renewal of Hematopoietic Stem Cells Mediated by the Polycomb Gene Product Bmi-1,”Immunity21:843-851 (2004).
Mikula et al., “Immortalized p19ARFNull Hepatocytes Restore Liver Injury and Generate Hepatic Progenitors After Transplantation,”Hepatology39(3):628-634 (2004).

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