Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-01-30
2011-11-01
Harris, Alana M. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007200, C435S007230, C435S040500, C435S040520
Reexamination Certificate
active
08048640
ABSTRACT:
Provide is a method for evaluating test agents as candidates for treating prostatic diseases, including benign prostatic hyperplasia (BPH) and androgen dependent and androgen independent prostate cancer. The method comprises providing a mouse comprising a human prostate primary xenograft, where the xenograft contains blood vessels that include human endothelial cells, initiating androgen deprivation in the mouse, administering to the mouse a test agent within a period of 1-7 days after initiating the androgen deprivation, and determining a reduction in human epithelial cells in the xenografts and/or a reduction in number of the endothelial cells or blood vessels in the xenograft. Also provided is a method for treating an individual for human prostate cancer or benign prostatic hyperplasia. The method comprises initiating androgen deprivation in the individual and administering to the individual an agent capable of inducing apoptosis of vascular endothelial cells within a period of 1-7 days of initiating androgen deprivation.
REFERENCES:
Huss, W.J. et al. The Prostate, 60: 77-90, 2004.
Presnell, S. C. et al. American Journal of Pathology, 159(3): 855-860, 2001.
Singh, R.P. et al., Cancer Epidemiology, Biomarkers & Prevention, 12: 933-939, 2003.
Sato, F., et al. Neoplasia, 7(9): 838-846, 2005.
Danny R. Gray, et al. Short-Term Human Prostate Primary Xenografts: An in Vivo Model of Human Prostate Cancer Vasculature and Angiogenesis. Cancer Research 64, 1712-1721, Mar. 1, 2004.
Gray Danny R.
Huss Wendy
Reisner Howard M.
Smith Gary J.
Harris Alana M.
Health Research , Inc.
Hodgson & Russ LLP
Holleran Anne
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