Methods for enlarging the diameter of a biological conduit...

Details Methods for enlarging the diameter of a biological conduit... Methods for enlarging the diameter of a biological conduit...

2008-04-10

2009-12-15

Weber, Jon P (Department: 1657)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C604S507000, C604S509000

Reexamination Certificate

active

07632494

ABSTRACT:
The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.

REFERENCES:
patent: 4636195 (1987-01-01), Wolinsky
patent: 4803294 (1989-02-01), Mueller et al.
patent: 4968614 (1990-11-01), Takiguchi et al.
patent: 4985361 (1991-01-01), Takiguchi et al.
patent: 5041091 (1991-08-01), Herring
patent: 5116615 (1992-05-01), Gokcen et al.
patent: 5162205 (1992-11-01), Takiguichi et al.
patent: 5212068 (1993-05-01), Takiguchi et al.
patent: 5397694 (1995-03-01), Atkinson et al.
patent: 5489261 (1996-02-01), Franzblau et al.
patent: 5710035 (1998-01-01), Greene et al.
patent: 5834449 (1998-11-01), Thompson et al.
patent: 5922322 (1999-07-01), Bini
patent: 5944710 (1999-08-01), Dev et al.
patent: 6074659 (2000-06-01), Kunz et al.
patent: 6074664 (2000-06-01), Roreger et al.
patent: 6143744 (2000-11-01), Broka et al.
patent: 6347247 (2002-02-01), Dev et al.
patent: WO 96/18725 (1996-06-01), None
Abbruzzese, T. et al.,Surgery, 124:328-335 (1998).
Altes et al.,AJR. 174:349-354 (Feb. 2000).
Anidjar, S. et al.,Ann. Vasc. Surg., 8(2):127-136 (1994).
Anidjar, S. et al.,Journal of Vascular Surgery, 16(2):139-147(1992).
Anidjar, S. et al.,Circulation82(3):973-981 (1990).
Arakawa, M. et al.,Japanese Journal of Clinical and Experimental Medicine, 62(3):1-15 (1985).
Carsten, C. et al.,Journal of Vascular Surgery, 33(6):1255-1262 (2001).
Cloft, H. et al.,Radiology, 213:223-228 (1999).
Curci, J. et al.Journal of Vascular Surgery, 385 (Feb. 1999).
Dobrin, P. et al.,Surgery, 104(3):568-571 (1988).
Dobrin, P. et al.,Arch. Surg., 119:405-409 (1984).
Erlendsson, L. et al.,Comparative Biochemistry and Physiology, Part B, 120:549-557 (1998).
Fujiwara, N. et al.,Am. J. Neuroradiol. 22:698-703 (2001).
Geary, R. et al.,Journal of Vascular Surgery, 27(1):96-108 (1998).
Hammond, G. et al.,J. Surgical Research, 12(4):313-317 (1972).
Hasegawa, M.Biorheology, 20(5):531-545 (1983).
Johnson, MS et al. The Porcine Hemodialysis Access Model,Journal of Vascular and Interventional Radiology2001;12(8):969-977.
Kabemba, J. et al.,Surgery, 73(3):438-443 (1973).
Kitoh, T. et al., American Journal of Physiology, 265(1 Pt 2):H273-80 (1993).
Lafont, A. et al.,Seminars in Interventional Cardiology, 2:177-182 (1997).
Maillard, L. et al.,Gene Therapy, 5:1023-1030 (1998).
Matsushita, M. et al.,Eur. Surg. Res. 31:305-313 (1999).
Miskolczi, L. et al.,Neurosurgery, 41(1):220-229 (1997).
Miskolczi, L. et al.,Neurosurgery, 43(3):595-600 (1998).
Moore, G. et al.,Journal of Vascular Surgery, 2993):522-532 (1999).
Muto, Y. et al.,Japan J. Surg., 16(3):225-230 (1986).
Ooyama, T. et al.,The Molecular Biology and Pathology of Elastic Tissues, Wiley, Chichester (Ciba Foundation Symposium 192), pp. 307-320 (1995).
Origuchi, N. et al.,International Angiology, 17(2):113-119 (1998).
Osman, M. et al.,J. Lab Clin. Med., 105(2):254-258 (1985).
Petrinec, D. et al.Journal of Vascular Surgery, 23(2):336-46 (1996).
Senior, R. et al.J. Biol. Chem. 266(12):7870-7875 (1991).
Singleton, P. et al. ,Dictionary of Microbiology and Molecular Biology(2nd ed. 1987, reprinted 1991), John Wiley and Sons, p. 320.
Strauss, BH et al.Extracellular Matrix Remodeling After Balloon Angioplasty Injury in a Rabbit Model of Restenosis Circulation Research., 75(4):650-658 (1994).
Strindberg, G. et al.,Journal of Investigative Surgery, 11(3):185-197 (1998).
White, J. et al.,Journal of Vascular Surgery, 17(2):371-381 (1993).
White, J.Journal of Vascular Surgery, 20(1):153-155 (1994).
White, J.V. et al.,Ann. NY Acad. Sci. 800:97-120 (Nov. 18, 1996).
Wilensky, RL et al.,Circulation; 92(10):2995-3005 (1995).
Dobrin & Mrkvicka,Cardiovas. Surg., 2(4): 484-488 (1994).
Trubel et al.,Eur J. Vasc. Endovasc. Surg., 10: 415-423 (1995).
Chernoyarova, O.D. and Podol'Skii, A.E. Mechanism of action of active elastase on pancreatic tissue. Bulletin of Experimental Biology and Medicine 78: 1340-1342 (1974).
Restriction Requirement mailed May 11, 2009 in U.S. Appl. No. 10/546,523.

Affiliated with

Also associated with

Rating

Methods for enlarging the diameter of a biological conduit... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for enlarging the diameter of a biological conduit..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for enlarging the diameter of a biological conduit... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4114213