Methods for enhancing the production of interferon in cell cultu

Details Methods for enhancing the production of interferon in cell cultu Methods for enhancing the production of interferon in cell cultu

1999-11-19

2000-12-12

Kemmerer, Elizabeth

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 6951, 435194, 435360, 530350, C12P 2102, C12N 1519, C07K 1456, C07K 14565

Patent

active

061597120

ABSTRACT:
Methods for enhancing the production of interferons in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain inducers of interferon production, in particular cellular levels of double-stranded-RNA-dependent kinase (dsRNA-PKR, or PKR). In cell cultures that overproduce PKR, interferon synthesis is induced to high levels, and significant amounts of interferon can be recovered without conventional induction of interferon by virus.

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