Methods for enhancing magnetic resonance imaging

Details Methods for enhancing magnetic resonance imaging Methods for enhancing magnetic resonance imaging

1985-02-06

1990-12-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653A, 128654, 534 13, A61K 4900

Patent

active

049801481

ABSTRACT:
Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of O, S, CHOH and CHSH, are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative manganese and gadolinium complexes of such compounds include disodium [[ethylenebis(oxyethylenenitrilo)]tetraaceto]-manganese(II), disodium [[(2-hydroxytrimethylene)dinitrilo]-tetraaceto]manganese(II), sodium [[(2-hyroxytrimethylene)dinitrilo]tetraaceto)gadolinium(III).

REFERENCES:
patent: 4472509 (1984-09-01), Ganson et al.
patent: 4647447 (1987-03-01), Gries et al.
Runge et al., AJR, vol. 141, (1983), pp. 1209-1215.
Martell et al., Chemistry of the Metal Chelate Compounds, Prentice-Hall, Inc., (1952), pp. 181-183.
Sigma, Biochemical and Organic Compounds, Price List, Feb. 1982, p. 306, E4378.
Chemical Abstracts, vol. 98, no. 1, (1983), 98:3795x.

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