Methods for enhancing graft survival by modulating heme...

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Reexamination Certificate

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C424S093200, C424S093210, C435S320100, C435S325000, C435S455000

Reexamination Certificate

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06861414

ABSTRACT:
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.

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