Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-06-26
2007-06-26
Carlson, Karen Cochrane (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
Reexamination Certificate
active
11358581
ABSTRACT:
The present invention provides two novelE. colisynthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from anE. coliexpression system.
REFERENCES:
patent: 4551433 (1985-11-01), DeBoer
patent: 5545541 (1996-08-01), Molin et al.
patent: 2002/0085998 (2002-07-01), Jiang et al.
Amann et al.,Gene 25(2-3):167-178, 1983.
Boer et al.,Proc. Natl. Acad. Sci. 80(1):21-25, Jan. 1983.
Estrem et al.,Proc. Natl. Acad. Sci. USA 95(17):9761-9766, Aug. 1998.
Fernanadez et al.,Gene Expression Systems: Using Nature for the Art of Expression, Ch. 2, pp. 45-64, Academic Press, San Diego, 1999.
Ford et al.,Protein Expression and Purification 2(2-3):95-107, 1991.
Goldstein et al.,Biotechnol. Annu. Rev. 1:105-125, 1995.
Grussenmeyer et al.,Proc. Natl. Acad. Sci. USA 82(23):7952-7954, Dec. 1985.
Hopp et al.,Biotechnology 6:1204-1210, Oct. 1988.
Lee et al.,Cell 66(4):793-798, 1991.
Lisser et al.,Nucleic Acids Res. 21(7):1507-1516, 1993.
Mosrin-Huaman et al.,Mol. Mircobiol 51(5):1471-1481, 2004.
Nilsson et al.,EMBO J. 4(4):1075-1080, 1985.
Nilsson et al.,Methods Enzymol. 198:3-16, 1991.
Ross,J. Bacteriol. 180(20):5375-5383, Oct. 1998.
Smith et al.,Gene 67(1):31-40, 1988.
Straney et al.,Cell 51(5):699-707, Dec. 4, 1987.
Chan Chung
Pownder Tracey A.
Carlson Karen Cochrane
Rooke Agnes B.
Walker Shelby J.
ZymoGenetics Inc.
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