Methods for enhancing angiogenesis with endothelial progenitor c

Details Methods for enhancing angiogenesis with endothelial progenitor c Methods for enhancing angiogenesis with endothelial progenitor c

1996-11-08

1999-11-09

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424 851, 424 852, 514 8, 514 44, A61K 3512, A61K 4800, A61K 3818, A61K 3819

Patent

active

059808870

ABSTRACT:
In accordance with the present invention, EC progenitors can be used in a method for regulating angiogenesis, i.e., enhancing or inhibiting blood vessel formation, in a selected patient and in some preferred embodiments for targetting specific locations. For example, the EC progenitors can be used to enhance angiogenesis or to deliver an angiogenesis modulator, e.g. anti- or pro-angiogenic agents, respectively to sites of pathologic or utilitarian angiogenesis. Additionally, in another embodiment, EC progenitors can be used to induce reendothelialization of an injured blood vessel, and thus reduce restenosis by indirectly inhibiting smooth muscle cell proliferation.

REFERENCES:
patent: 5612211 (1997-03-01), Wilson et al.
patent: 5652225 (1997-07-01), Isner
Isner, et al., The Lance, 348:370-374 (1996) (previously submitted.
XP-002059362-Asahara, et al. "In Vitro Evidence for Endothelial Cell Precursors in Peripheral Blood". Circulation 84(8) p. I-102 (1996).
XP-002059358-Asahara, et al. "Blood Cell Drived Endothelial Cell Precursor Can Participate . . . " Circulation 94(8) p. I237 (1996) Dec. 7, 1998.
Asahara, et al., Science 275: 964-967 (1997) (previously submitted).
Takeshita, et al., Lab. Inves., 75:4, 487-501(1996) (previously submitted).
Schnurch et al. Development 119: 957-968 (1993).
Yamaguchi et al. Development 118: 489-498 (1993).
Fennie et al. Blood 86: 4454-4467 (1995).
Baumgartner et al. Circulation 97: 1114-1123 (1998) Abstract Only.
Tsurumi et al. Circulation 96 (9 Suppl)II: 382-388 (1997) Abstract Only.
Asahara et al. Science 275: 964-967 (1997).
Asahara et al. Circulation 94(8 Suppl) I237 (1996).
Asahara et al. Circulation 92(Suppl II) II-365-371 (1995).
Bik Falvi et al. Leukemia 8:523-529 (1994).
Noishiki et al. Nature Medicine 2:90-92 (1996).
Shi et al. J Vas Surg 20: 546-557 (1994).
Folkman and Shing, J. Biol. Chem. 267 (16), 10931-109034 (1992).
Baffour, et al., J Vasc Surg, 16:181-91 (1992).
Takeshita, et al., Circulation, 90:228-234 (1994).
Takeshita, et al., Laboratory Investigation, 75:487-502 (1996).
Yanagisawa-Miwa, et al., Science, 257:1401-1403 (1992).
Pu, et al., J Surg Res, 54:575-83 (1993).
Isner, et al., Lancet, 348:370 (1996).
Takeshita, et al., J Clin Invest, 93:662-70 (1994).

Affiliated with

Also associated with

Rating

Methods for enhancing angiogenesis with endothelial progenitor c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for enhancing angiogenesis with endothelial progenitor c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for enhancing angiogenesis with endothelial progenitor c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1451785