Methods for enhancement of protective immune responses

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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4241841, 424450, 514 12, A61K 3900, A61K 39002, A61K 39008, A61K 9127

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active

058767355

ABSTRACT:
Methods for eliciting or enhancing immune responses to antigens, including tumor antigens, are provided. The methods employ polypeptides or nucleic acid compositions that contain at least a biologically active portion of a Leishmania braziliensis or Leishmania major homologue of the eukaryotic initiation factor 4A, or a variant thereof. Such polypeptides and compositions are useful for enhancing or eliciting a patient's cellular and/or humoral immune response, for instance within methods for treating tumors.

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