Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2006-08-01
2006-08-01
Nguyen, Dave Trong (Department: 1633)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S456000, C435S069100, C435S372000, C435S320100, C424S093200, C530S350000, C530S300000
Reexamination Certificate
active
07083979
ABSTRACT:
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.
REFERENCES:
patent: 4727059 (1988-02-01), Binder
patent: 4839464 (1989-06-01), McCarthy
patent: 4980279 (1990-12-01), Peters
patent: 5004681 (1991-04-01), Boyse
patent: 5019646 (1991-05-01), Furcht
patent: 5102988 (1992-04-01), Kimizuka
patent: 5116368 (1992-05-01), McCarthy
patent: 5124155 (1992-06-01), Reich
patent: 5175096 (1992-12-01), Hook
patent: 5188959 (1993-02-01), Haberman
patent: 5198423 (1993-03-01), Taguchi et al.
patent: 5229172 (1993-07-01), Cahalan et al.
patent: 5299172 (1994-03-01), Badger
patent: 5354686 (1994-10-01), Haberman
patent: 5405772 (1995-04-01), Ponting
patent: 5409825 (1995-04-01), Hoffman
patent: 5670351 (1997-09-01), Emerson et al.
patent: 5686278 (1997-11-01), Williams et al.
patent: 6033907 (2000-03-01), Williams
patent: 6051427 (2000-04-01), Finer et al.
patent: 0 349 342 (1990-01-01), None
patent: 0 399 806 (1990-01-01), None
patent: 2 311498 (1989-12-01), None
patent: 2 97397 (1990-09-01), None
patent: WO 90/13641 (1990-11-01), None
patent: WO 93/18137 (1993-09-01), None
patent: WO 94/02610 (1994-02-01), None
patent: WO 95/26200 (1995-10-01), None
AN 1999219789, Medline, Gene therapy.
Kohn, MD, The current status of gene therapy using hematopietic stem cells, 1995, Current Science in Pediatrics, vol. 5, pp. 56-63.
Moritz et al., Bone Marrow Extracelluar Matrix Molecules Improve Gene Transfer in Human Hematopoietic Cells via Retroviral Vectors, Apr. 1994, J. Clin. Invest., vol. 93, pp. 1451-1457.
Moritz et al., Human Cord Blood Cells as Targets for Gene Transfer: Potential Use in Genetic Therapies of Severe Combined Immunodeficiency Disease, Aug. 1993, vol. 178, pp. 529-536.
Williams et al., Umbilical Cord Blood Stem Cells as Targets for Genetic Modification: New Therapeutic Approaches to Somatic Gene therapy, 1994, Blood Cells, vol. 20, pp. 504-516.
Riddell et al., T-cell medicated rejection of gene-modified HIV-specific cytotoxic T lymphocytesa in HIV-infected patients, Feb. 1996, Nature, vol. 2, No. 2, pp. 216-223.
Anderson, Human gene therapy, Apr. 30, 1998, Nature, vol. 392, pp. 25-30.
Verma et al., Gene therapy-promises, problems and prospects, Sep. 18, 1997, Nature, vol. 389, pp. 239-242.
Ngo et al., Computational Complexity Protein Structure Prediction, and the Levinthal Paradox, 1994, Birkhauser Boston, pp. 492-495.
Hoogerburgg et al., Bone marrow gene transfer in three patients with adeosine deaminase deficiency, 1993, Gene Therapy, vol. 3, pp. 179-183.
AN 1999219789, Medline, Gene therapy, 1999.
Kohn, MD, The current status of gene therapy using hematopietic stem cells, 1995, Current Science in Pediatrics, vol. 5, pp. 56-63.
Moritz et al., Bone Marrow Extracelluar Matrix Molecules Improve Gene Transfer in Human Hematopoietic Cells via Retroviral Vectors, Apr. 1994, J. Clin. Invest., vol. 93, pp. 1451-1457.
Moritz et al., Human Cord Blood Cells as Targets for Gene Transfer: Potential Use in Genetic Therapies of Severe Combined Immunodeficiency Disease, Aug. 1993, vol. 178, pp. 529-536.
Verma, IM et al., “Gene therapy-promises, problems, and prospects”, Nature, 1997, vol./Issue No. 389, pp. 239-242.
“Bubble Boy saved by gene therapy”, BBC News, Apr. 3, 2000.
“Cell-Cell Adhesion and the Extracellular Matrix”, Molecular Biology of the Cell, 1983, pp. 673-713, Garland Publishing Co., New York.
Anderson, W. French, “Prospects for Human Gene Therapy”, Science, 1984, vol. 226 (4673) pp. 401-409.
Anderson, W. French, “Human Genes Therapy—SCIENCE”, SCIENCE, May 8, 1992, vol./Issue No. 258, pp. 808-813.
Apperley, J.F., et al., “Retroviral Gene Transfer of Human Adenosine Deaminase in Murine Hematopoiatic Cells: Effect of Selectable Marker Sequences on Long-Term Expression”, Amer. Soc. Hematology 1991 pp. 310-317.
Ashwell, G. et al., “Carbohydrate-Specific Receptors of the Liver”, Ann. Rev. Biochem, 1982, vol./Issue No. 61, pp. 631-664.
Bernardi et al., “Lymphoid Precursor Cells Adhere to Two Different Sites on Fibronectin”, J. Cell Biol., 1987, vol./Issue No. 106, pp. 489-498.
Bienzle, Dorothee et al., “Gene transfer into hematopoietic stem cells: Long-term maintenance on in vitro activated progenitors without marrow ablation”, Proc. Natl. Acad. Sci. USA, 1994, vol./Issue No. 91, pp. 350-354.
Bodine, D.M. et al., “Long-term in vivo expression of a Murine Adenosine Deaminase Gene in Rhesus Monkey Hematopoietic Cells of Multiple Lineages After Retroviral-mediated Gene Transfer into CD34+ Bone Marrow Cells” Blood 1993 vol./Issue No. 82:7 pp. 1975-1980.
Bodine, David M., et al., “Development of a High-Titer Retrovirus Producer Cell Line Capable of Gene Transfer into Rhesus Monkey Hematopoietic Stem Cells”, Proc. Natl. Acad. Sci. USA, 1990, vol./Issue No. 87, pp. 3738-3742.
Bradley, T.R. et al., “The Growth of Mouse Bone Marrow Cells in Vitro”, Aust. J. Exp. Biol. Med. Sci., 1966, vol./Issue No. 44, pp. 287-300.
Broxmeyer, H.E. et al., “Umbilical Cord Blood Hematopoietic Stem and Repopulating Cells in Human Clinical Transplantation”, Blood Cells, 1991, vol./Issue No. 17, pp. 313-329.
Carter, et al., “Autologous Transplantation of Canine Long-Term Marrow Culture Cells Genetically Marked by Retroviral Vectors”, Blood, 1992, vol./Issue No. 79:2, pp. 356-364.
Cornetta, et al., “Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy”, Journal of Virological Methods, 1989, vol./Issue No. 23, pp. 187-194.
Cristiano, R.J., et al., “Hepatic Gene Therapy: Adenovirus Enhancement of Receptor-Mediated Gene Delivery and Expression in Primary Hepatocytes”, Proc. Natl. Acad. Sci. USA, 1993, vol./Issue No. 90, pp. 2122-2126.
Dilber, MS. et al., “Basic fibroblast growth factor increases retroviral-mediated gene transfer into human hematopoietic peripheral blood progenitor cells”, Exp. Hematol, 1994, vol./Issue No. 22:12, pp. 1129-1133.
Emons, G. et al., “The Use of Luteinizing Hormone Releasing Hormone Agonists and Antagonists in Gynecological Cancers”, Hum. Reprod., 1994, vol./Issue No. 9:7,pp. 1364-1379.
Fichard et al., “Another Look at Collagen V and XI Molecules”, Matix Biology, 1994, vol./Issue No. 14, pp. 515-531.
Flasshove, M. et al., “Increased resistance to taxol for peripheral blood progenitor cells following transduction with an MDR1-encoding retroviral vector”, Exp. Hematol., 1995, vol./Issue No. Abstract 23/8 pp. 934.
Flasshove, Michale, et al., “Ex Vivo Expansion and Selection of Human CD34+ Peripheral Blood Progenitor Cells After Introduction of a Mutated Dihydrofolate Reductase cDNA via Retroviral Gene Transfer”, Blood Jan. 2, 1995 vol./Issue No. 85-2 pp. 566-574.
Friedmann, Theodore, “Progress Toward Human Gene Therapy”, Science, Jun. 1989, pp. 1276-1281.
Gluckman, E. et al., “Bone Marrow Transplantation in Fanconi Anaemia”, British J. of Haem., 1980, vol./Issue No. 45, pp. 557-564.
Hanenberg, A. et al., “Rapid and efficient transduction of primitive hematopholetic cells; role of retrovirus adhesion in fibronectin assisted gene transfer”, Blood, 1995, vol./Issue No. 86:10, pp. 465a.
Haraguchi et al., “Effects of Polycations on Infection with Human Retroviruses”, Int. Conf. AIDS, 1994,
Patel Vikram P
Williams David A
Indiana University Foundation
Marvich Maria
Nguyen Dave Trong
Woodard Emhardt Moriarty McNett & Henry LLP
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