Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Reexamination Certificate
2007-08-21
2007-08-21
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
C435S255100, C435S254200, C435S254230, C435S069100, C435S483000
Reexamination Certificate
active
11020808
ABSTRACT:
The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genusPichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolatedP. pastorisMNN4B gene. The present invention further relates to methods for producing modified glycan structures in host cells that are free of glycan mannosylphosphorylation.
REFERENCES:
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patent: 1 283 265 (2001-05-01), None
patent: WO 01/88143 (2001-02-01), None
patent: WO 01/88143 (2001-11-01), None
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Bobrowicz Piotr
Stadheim Terrance A.
Wildt Stefan
GlycoFi, Inc.
Krovatin William
Meah Mohammad
Prouty Rebecca E.
Reilly John David
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