Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1996-10-04
1999-07-27
Marschel, Ardin H.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
422 50, 422 62, 422 681, 422 69, 422 8205, 422129, 422131, 422134, 4352831, 4352851, 4352852, 4352861, 4352862, 4352871, 4352872, 4352879, 4352883, 4352891, 4352991, 4353051, 530334, 536 253, A61K 3800, C07H 2100
Patent
active
059292083
ABSTRACT:
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
REFERENCES:
patent: 3950738 (1976-04-01), Hayashi et al.
patent: 3995190 (1976-11-01), Salgo
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4580895 (1986-04-01), Patel
patent: 4584075 (1986-04-01), Goldstein
patent: 4594135 (1986-06-01), Goldstein
patent: 4751177 (1988-06-01), Stabinsky
patent: 4787963 (1988-11-01), MacConnell
patent: 4816418 (1989-03-01), Mack et al.
patent: 4822566 (1989-04-01), Newman
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4908112 (1990-03-01), Pace
patent: 5063081 (1991-11-01), Cozzette et al.
patent: 5074977 (1991-12-01), Cheung et al.
patent: 5075077 (1991-12-01), Durley, III et al.
patent: 5096669 (1992-03-01), Lauks et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5125748 (1992-06-01), Bjornson et al.
patent: 5126022 (1992-06-01), Soane et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5164319 (1992-11-01), Hafeman et al.
patent: 5166063 (1992-11-01), Johnson
patent: 5200051 (1993-04-01), Cozzette et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5219726 (1993-06-01), Evans
patent: 5227265 (1993-07-01), DeBoer et al.
patent: 5234566 (1993-08-01), Osman et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5312527 (1994-05-01), Mikkelsen et al.
patent: 5434049 (1995-07-01), Okano et al.
patent: 5527670 (1996-06-01), Stanley
patent: 5653939 (1997-08-01), Hollis et al.
patent: 5681751 (1997-10-01), Begg et al.
Anand and Southern, "Pulsed field gel electrophoresis," Gel Electrophoresis of Nucleic Acids--A Practical Approach, 2d edition, eds. D. Rickwood and B.D. Hames, (New York:IRL Press 1990) pp. 101-123.
Anderson and Young, "Quantitative Filter Hybridisation," Nucleic Acid Hybridization--A Practical Approach, eds. B.D. Hames and S.J. Higgins (Washington DC:IRL Press 1985) pp. 73-111.
Bains, "Setting a Sequence to Sequence a Sequence," Bio/Technology, 10:757-758 (1992).
Barinaga, "Will `DNA Chip` Speed Genome Initiative?" Science, 253:1489 (1991).
Beattie et al., "Genosensor Technology," The 1992 San Diego Conference: Genetic Recognition, pp. 1-5, (Nov., 1992).
Beltz et al., "Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods," Methods in Enzymology, 100:266-285 (1983).
Connor et al., "Detection of sickle cell .beta..sup.3 -globin allele by hybridization with synthetic oligonucleotides," Proc. Natl. Acad. Sci. USA, 80:278-282 (1983).
Drmanac et al., "Sequencing of Megabase Plus DNA by Hybridization: Theory of the Method," Genomics, 4:114-128 (1989).
Drmanac et al., "DNA Sequence Determination by Hybridization: A Strategy for Efficient Large-Scale Sequencing," 260:1649-1652 (1993).
Fodor et al., "Multiplexed biochemical assays with biological chips," Nature, 364:555-556 (1993).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis," Science, 251:767-773 (1991).
Horejsi, "Some Theoretical Aspects of Affinity Electrophoresis," Journal of Chromatography, 178:1-13 (1979).
Horejsi et al., "Determination of Dissociation Constants of Lectin Sugar Complexes by Means of Affinity Electrophoresis," Biochimica et biophysica acta, 499:290-300 (1977).
Ranki et al., "Sandwich hybridization as a convenient method for the detection of nucleic acids in crude samples," Gene, 21:77-85 (1983).
Saiki, "Amplification of Genomic DNA," PCR Protocols: A Guide to Methods and Applications, (Academic Press, Inc. 1990) pp. 13-20.
Southern et al., "Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation Using Experimental Models," Genomics, 13:1008-1017 (1992).
Strezoska et al., "DNA sequencing by hybridization: 100 bases read by a non-gel-based method," Proc. Natl. Acad. Sci. USA, 88:100898-10093 (1991).
Wallace et al., "Hybridization of synthetic oligodcoxyribonucleotides to .PHI. .sub.x 174 DNA: the effect of single base pair mismatch," Nucleic Acid Res., 6:3543-3557 (1979).
Washizu, "Electrostatic manipulation of biological objects," Journal of Electrostatics, 25:109-123 (1990).
Washizu and Kurosawa, "Electrostatic Manipulation of DNA in Microfabricated Structures," IEEE Transactions on Industry Applications, 26:1165-1172 (1990).
Brown et al, "Electrochemically Induced Adsorption of Radio-Labelled DNA on Gold and HOPG Substrates for STM Investigations", Ultramicroscopy 38 (1991) 253-264.
Washizu, et al, "Electrostatic Manipulation of DNA in Microfabricated Structures", IEEE Transactions on Industrial Applications, vol. 26, No. 6, Nov./Dec., 1990, pp. 1165-1172.
Palecek, "New Trends in Electrochemical Analysis of Nucleic Acids", Bioelectrochemistry and Bioenergetics, 20 (1988), pp. 179-194.
BioChip Technology Development, Lincoln Laboratory Technical Report 901, Nov. 9, 1990.
Abrams et al., "Comprehensive Detection of Single Base Changes in Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis and a GC Clamp", Genomics, vol. 7, 1990, pp. 463-475.
Heller Michael J.
Tu Eugene
Marschel Ardin H.
Nanogen Inc.
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