Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1996-10-01
1998-06-09
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514171, 514179, 514182, A61K 3118, A61K 3156
Patent
active
057634920
ABSTRACT:
This invention discloses a method for enhancing memory in a patient comprising administering a compound of formula ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen and a lower alkyl group; m is an integer between about 0 and 4; and n is an integer between about 5 and 14. The methods generally comprise administering an effective amount of the compound. The invention also discloses the enhancement of memory by the use of non-steroidal sulfatase inhibitors of the above formula in conjunction with the naturally occurring neurosteroids dehydroepiandrosterone sulfate (DHEAS) and/or pregnenolone sulfate (PS). The patients benefitting from the methods of the present invention will generally have an illness that causes memory loss, or will be individuals who otherwise want to improve memory.
REFERENCES:
patent: 5556847 (1996-09-01), Johnson et al.
patent: 5567831 (1996-10-01), Li
Johnson David A.
Li Pui-Kai
Duguesne University of the Holy Ghost
Jarvis William R. A.
Meyers Diane R.
Silverman Arnold B.
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