Methods for disinfecting dialyzers

Liquid purification or separation – Processes – Chemical treatment

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210646, 210749, 422 1, 422 26, 422 27, 422 28, B01D 6502, B01D 6506, A61L 216

Patent

active

054805651

ABSTRACT:
A method for reprocessing dialyzer cartridges used with kidney dialysis machines is provided. The method involves filling the blood and dialysate compartments of the dialyzer with an aqueous solution containing citric acid at a concentration of 1.0-5.0 wt. %, e.g., 1.5 wt. %, and then subjecting the dialyzer to an elevated temperature above 90.degree. C. and below 100.degree. C., e.g., 95.degree. C., for a period of at least 15 hours, e.g., 20 hours. Although citric acid is non-toxic and the temperature used is below the boiling point of water, the process has been found to produce a fully sterilized dialyzer. After reprocessing, the aqueous citric acid solution is preferably left in the dialyzer where it acts as a bacteriostatic agent during storage. Essentially no damage to the dialyzer and, in particular, to its semipermeable membrane results from either the reprocessing or storage procedures.

REFERENCES:
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patent: 4690772 (1987-09-01), Tell et al.
patent: 4695385 (1987-09-01), Boag
patent: 5173125 (1992-12-01), Felding
patent: 5192459 (1993-03-01), Tell et al.
patent: 5304349 (1994-04-01), Polaschegg
Deane et al., "Multiple Use of Hemodialyzers," In: Replacement of Renal Function by Dialysis, 3rd edition, edited by J. F. Maher, Kluwer Academic Publishers, Boston, Mass., 1989, pp. 400-416.
Reuse of Hemodialyzers--AAMI Recommended Practice for Reprocessing Hemodialyzers, ANSI/AAMI RD 47, Association for the Advancement of Medical Instrumentation, Arlington Va., 1993, pp. i-vii and 1-25.
Kaufman et al., "Clinical Experience with Heat Sterilization for Reprocessing Dialyzers," ASAIO Transactions, vol. 38, No. 3, Jul.-Sep. 1992, pp. M338-M340.

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