Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-10-09
2007-10-09
Yaen, Christopher H. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
11506688
ABSTRACT:
A method for identifying low grade astrocytoma cells in a sample is provided, wherein the method distinguishes between low grade astrocytoma cells and normal astrocytes, thus permitting early diagnosis of astrocytoma. The method uses antibody directed against J1-31 to test astrocytes in the sample for the presence or absence of J1-31 polypeptide, the low grade astrocytoma cells being characterized by the absence of J1-31 while normal astrocytes are characterized by the presence of J1-31.
REFERENCES:
patent: 5807692 (1998-09-01), Kinzler et al.
Bhatnagar et al., Cytobios, 1995, 82(331): 239-49.
Malhotra et al., “A Monoclonal Antibody for Cytoskeletal Antigenic Determinant(s) Distinguishable from Glial Fibrillary Acidic Protein in Astrocytes”, Microbios Letters, 1984, vol. 26, pp. 151-157.
Malhotra et al., “Diversity Among Reactive Astrocytes: Proximal Reactive Astrocytes in Lacerated Spinal cord Preferentially React with Monoclonal Antibody J1-31”, Brain Research Bulletin, 1993, vol. 30, pp. 395-404.
Malhotra et al., “Novel Astrocytic Protein in Multiple Sclerosis Plaques”, Journal of Neuroscience Research, 1989, vol. 22, pp. 36-49.
Predy et al., “A New Protein (J1-31 Antigen, 30kD) is Expressed by Astrocytes, Müller Glia and Ependyma”, Bioscience Reports, 1987, vol. 7, No. 6, pp. 491-502.
Predy et al., “Enhanced Expression of a Protein Antigen (J1-31 Antigen, 30 Kilodaltons) by Reactive Astrocytes in Lacerated Spinal Cord,” Journal of Neuroscience Research, 1988, vol. 19, pp. 397-404.
Singh et al., “A New ‘Marker’ Protein for Astrocytes”, Bioscience Reports, 1986, vol. 6, No. 1, pp. 73-80.
Singh et al., “J1-31 Antigen of Astrocytes: Cytoplasmic and Nuclear Localization”, Dendron, 1992, vol. 1, pp. 91-108.
Singh et al., “Novel Rod-Shaped Structures Identified in Glioma Cell Nuclei by Immunolabelling and Confocal Laser Fluorescence Microscopy”, Biomedical Letters, 1994, vol. 50, pp. 163-172.
Stratagene Catalog, 1998, cover pg., p. 39.
Imam S. Ashraf
Malhotra Sudarshan
Christie Parker & Hale LLP
Governors of the University of Alberta
Huntington Medical Research Institutes
Sang Hong
Yaen Christopher H.
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