Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-03-05
2000-08-08
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C12Q 168
Patent
active
061000310
ABSTRACT:
The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers (e.g., colon cancer) in mammals, e.g., humans. The invention is based on the discovery of genes that are differentially expressed in tumor cells relative to normal cells. The genes identified can be used diagnostically or as targets for therapy, and can be used to identify compounds useful in the diagnosis, prevention, and therapy of tumors and cancers.
REFERENCES:
patent: 4835255 (1989-05-01), Weissman et al.
Alonso et al., "cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation" Proc. Nat'l. Acad. Sci. USA 84:1997-2001, 1987.
Auffrey et al., GenBank Accession No. 225283, 1995.
Beale et al., "Rat Hepatic Cytosolic Phosphoenolpyruvate Carboxykinase (GTP:" J. of Biol. Chem. 260(19):10748-10760, 1985.
Boring et al., "Cancer Statistics, 1993" CA-A Cancer Journal for Clinicians 43:7-26, 1993.
Donalies et al., "Expression of M-cadherin, a member of the cadherin multigene family, correlates with . . . " Proc. Nat'l. Acad. Sci. USA 88:8024-8028, 1991.
Gross et al., "cDNA sequence coding for a translationally controlled human tumor protein" Nucl. Acids Res. 17:8367, 1989.
Hiller et al., Accession No. AA196387, 1995.
Hoffman, "Orthotopic is Orthodox: Why are orthotopic-transplant metastatic models different from all other models?" J. of Cell. Biohem. 56:1-3, 1994.
Hunter, "Cooperation between Oncogenes" Cell 64:249-260, 1991.
Land, "Cellular Oncogenes and Multistep Carcinogenesis" Science 222:771-778, 1983.
Liang et al., "Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells" Cancer Res. 52:6966-6968, 1992.
Pallanck et al., "Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene," Human Mol. Genetics 3:1239-1243, 1994.
Robishaw et al. "Existence of two .gamma. subunits of the G proteins in brain" J. of Biol. Chem. 264:15758-15761, 1989.
Ruley "Adenovirus early retgion 1A enables viral and and cellular transforming genes to transform primary cells in culture" Nature 304:602-606, 1983.
Sano et al., "Protocadherins: a large family of cadherin-related molecules in central nervous system" The EMBO Journal 12:2249-2256, 1993.
Seaver "Monoclonal antibodies in industry: More difficult than originally thought" Genetics Engineering News 14:10-14, 1994.
Togo et al., "Host organ specifically determines cancer progression" Cancer Res. 55:681-684, 1995.
Vogelstein et al., "Allelotype of colorectal Carcinomas" Science 244:207-211, 1989.
Vogelstein et al., "The multistep nature of cancer" Trends in Genetics 9:138-141, 1993.
Wang et al., "Matrix metalloproteinase Inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice" Cancer Res. 54:4726-4728, 1994.
MP Search, Accession No. EO3314, Nov. 26, 1996.
Arthur Lisa B.
Enewold Jeanine
Millennium Pharmaceuticals Inc.
LandOfFree
Methods for diagnosis of colon cancer by detecting Roch083 mRNA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for diagnosis of colon cancer by detecting Roch083 mRNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for diagnosis of colon cancer by detecting Roch083 mRNA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1148801