Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-11-19
2009-10-06
Chernyshev, Olga N (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C702S019000, C702S023000, C600S300000
Reexamination Certificate
active
07598049
ABSTRACT:
The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4728605 (1988-03-01), Fudenberg et al.
patent: 5874312 (1999-02-01), Sredni et al.
patent: 6027896 (2000-02-01), Roses et al.
patent: 6114133 (2000-09-01), Seubert et al.
patent: 6130048 (2000-10-01), Nixon
patent: 6183971 (2001-02-01), Sasada et al.
patent: 6210895 (2001-04-01), Schipper et al.
patent: 6251639 (2001-06-01), Kurn
patent: 6358681 (2002-03-01), Ginsberg et al.
patent: 6451547 (2002-09-01), Jackowski et al.
patent: 6461831 (2002-10-01), Small et al.
patent: 6465195 (2002-10-01), Holtzman et al.
patent: 6475161 (2002-11-01), Teicher et al.
patent: 6495335 (2002-12-01), Chojkier et al.
patent: 6692918 (2004-02-01), Kurn
patent: 6699677 (2004-03-01), Schall et al.
patent: 2003/0064416 (2003-04-01), Jackowski et al.
patent: 2003/0119074 (2003-06-01), Jackowski et al.
patent: 2005/0255484 (2005-11-01), Valkirs et al.
patent: 2006/0094064 (2006-05-01), Ray et al.
patent: 2007/0037200 (2007-02-01), Ray et al.
patent: 1 050 758 (2000-11-01), None
patent: WO-02/44732 (2002-06-01), None
patent: WO-02/44732 (2002-06-01), None
patent: WO-2005/052592 (2005-06-01), None
patent: WO-2005/052592 (2005-06-01), None
patent: WO-2006/133423 (2006-12-01), None
Frey et al Neurochem Res. 2005, 30(12): 1501-10.
D'Asxenzo Curr Opin Mol Ther. 2005, 7(6): 557-64.
Thavasu et al J Immunol Methods. Aug. 30, 1992;153(1-2):115-24.
Rikkert et al (Neth J Med. 2003, 61(3): 83-87.
Ho et al Brain Research Reviews 48 (2005) 360-369.
Takahama et al Clin Cancer Res 1999, 5(9): 2506-10.
Brattström Lung Cancer, 2002, 37(1): 57-63.
Langenfeld Carcinogenesis. 2003, 24(9): 1445-54.
Mroczko et al Clin Chem Lab Med. 2001; 39(5): 374-9.
Hsieh et al Proteomics. 2006, 6(10):3189-98.
Cheung et al Nature Genetics, 2003, 33, 422-425.
Cobb et al (2002) (Crit Care Med. Dec. 2002;30(12):2711-21.
Chan E., et al Integrating Transcriptomics and Proteomics, Genomics and Proteomics.
Tarkowski et al Acta Neurol Scand. 2001;103(3):166-74.
Hoshikawa et al , Physiol Genomics 12: 209-219, 2003.
Behan et al. Journal of the American Academy of Geriatrics Society, 18(10):792-797, 1970.
Frank et al., Neurobiology of Aging, 24:521-536, 2003.
Hasegawa et al., Gerontology, 46: 185-188, Jul./Aug. 2000.
Blaber, S.I. et al. (Jan. 29, 2002). “Enzymatic Properties of Rat Myelencephalon-Specific Protease,”Biochemistry41(4):1165-1173.
Heese, K. et al. (2000). “Induction of Rat L-Phosphoserine Phosphatase by Amyloid-β (1-42) is Inhibited by Interleukin-11,”Neurosci Lett. 288(1):37-40.
Huberman, M. et al. (1994). “Correlation of Cytokine Secretion by Mononuclear Cells of Alzheimer Patients and Their Disease Stage,”J. Neuroimmunol. 52(2):147-152.
Patel, N.S. et al. (Mar. 11, 2005). “Inflammatory Cytokine Levels Correlate with Amyloid Load in Transgenic Mouse Models of Alzheimer's Disease,”J. Neuroinflammation2(1):9. (10 total pages).
Robakis, N.K. et al. (1991). “Expression of the Alzheimer's Amyloid Precursor in Brain Tissue and Effects of NGF and EGF on its Metabolism,”Clin. Neuropharmacol. 14(Suppl. 1):S15-S23.
Xia, M. et al. (Jul. 1998). “Immunohistochemical Study of the β-Chemokine Receptors CCR3 and CCR5 and Their Ligands in Normal and Alzheimer's Disease Brains,”Am. J. Pathol. 153(1):31-37.
Abraham, J.A. et al. (1986). “Human Basic Fibroblast Factor: Nucleotide Sequence and Genomic Organization,”EMBO J. 5(10):2523-2528.
Collins, T. et al. (Aug. 22, 1985). “Cultured Human Endothelial Cells Express Platelet-Derived Growth Factor B Chain: cDNA Cloning and Structural Analysis,”Nature316(6030):748-750.
Docherty, A.J.P. et al. (Nov. 7, 1985). “Sequence of Human Tissue Inhibitor of Metalloproteinases and its Identity to Erythroid-Potentiating Activity,”Nature318(6041):66-69.
Foster, D.C. et al. (Dec. 1994). “Human Thrombopoietin: Gene Structure, cDNA Sequence, Expression, and Chromosomal Localization,”Proc. Natl. Acad. Sci. U.S.A. 91(26):13023-13027.
Gasson, J.C. et al. (Jun. 27, 1985). “Molecular Characterization and Expression of the Gene Encoding Human Erythroid-Potentiating Activity,”Nature315(6022):768-771.
Gray, A. et al. (Jun. 23, 1983). “Nucleotide Sequence of Epidermal Growth Factor cDNA Predicts a 128,000-Molecular Weight Protein Precursor,”Nature303:722-725.
Gray, P.W. et al. (Dec. 20/27, 1984). “Cloning and Expression of cDNA for Human Lymphotoxin, a Lymphokine with Tumour Necrosis Activity,”Nature312(5996):721-724.
Hohn, A. et al. (Mar. 22, 1990). “Identification and Characterization of a Novel Member of the Nerve Growth Factor/Brain-Derived Neurotrophic Factor Family,”Nature344(6264):339-341.
Marics, I. et al. (Mar. 1989). “Characterization of theHST-relatedFGF.6 Gene, a New Member of the Fibroblast Growth Factor Gene Family,”Oncogene4(3):335-340.
Masuzaki, H. et al. (Jul. 1995). “HumanObeseGene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue,”Diabetes44(7):855-858.
Rosenthal, A. et al. (Sep. 1991). “Primary Structure and Biological Activity of Human Brain-Derived Neurotrophic Factor,”Endocrinology129(3):1289-1294.
Schall, T.J et al. (Apr. 20, 1990). “Molecular Cloning and Expression of a Receptor for Human Tumor Necrosis Factor,”Cell61(2):361-370.
Schall, T.J. et al. (Aug. 1, 1988). “A Human T Cell-Specific Molecule is a Member of a New Gene Family,”J. Immunol. 141(3):1018-1025.
Stetler-Stevenson, W.G. et al. (Aug. 15, 1990). “Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) mRNA Expression in Tumor Cell Lines and Human Tumor Tissues,”J. Biol. Chem. 265(23):13933-13938.
Taga, T. et al. (Aug. 11, 1989). “Interleukin-6 Triggers the Association of Its Receptor With a Possible Signal Transducer, gp130,”Cell58(3):573-581.
ten Dijke, P. et al. (Jul. 1988). “Identification of Another Member of the Transforming Growth Factor Type β Gene Family,”Proc. Natl. Acad. Sci. U.S.A. 85(13):4715-4719.
Walz, A. et al. (1991). “Formation and Biological Properties of Neutrophil Activating Peptide 2 (NAP-2),”Chemotactic Cytokines, pp. 39-46.
Wang, W. et al. (May 1998). “Molecular Cloning and Functional Characterization of Human MIP-1δ, a New C-C Chemokine Related to Mouse CCF-18 and C10,”J. Clin. Immunol. 18(3):214-222.
Yang, Y.-C. et al. (Oct. 10, 1986). “Human IL-3 (Multi-CSF): Identification by Expression Cloning of a Novel Hematopoietic Growth Factor Related to Murine IL-3,”Cell47(1):3-10.
Yoshikawa, W. et al. (Mar. 15, 1999). “Characterization of Free α- and β-Chains of Recombinant Macrophage-Stimulating Protein,”Arch. Biochem. Biophys. 363(2):356-360.
Yoshimura, T. et al. (Jul. 25, 1993). “Cloning, Sequencing, and Expression of Human Macrophage Stimulating Protein (MSP, MST1) Confirms MSP as a Member of the Family of Kringle Proteins and Locates the MSP Gene on Chromosome 3,”J. Biol. Chem. 268(21):15461-15468.
Zsebo, K.M. et al. (Oct. 5, 1990). “Stem Cell Factor is Encoded at theS/Locus of the Mouse and is the Ligand for the c-kitTyrosine Kinase Receptor,”Cell63(1):213-224.
Agrawal, R. et al. (May 1993). “Mining Association Rules Between Sets of Items in Large Databases,”Proc. of the 1993 ACM SIGMOD Conference on Management of Data, Washington, D.C., pp. 207-216.
Burbach, G.J. et al. (Mar. 10, 2004). “Induction of Brain-Derived Neurotrophic
Ray Sandip
Wyss-Coray Anton
Chernyshev Olga N
MacFarlane Stacey
Morrison & Foerster / LLP
Satoris, Inc.
The Borad of Trustees of the Leland Stanford Junior University
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