Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-03-20
2000-04-25
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435183, 435194, 436501, G01N 3353
Patent
active
060542802
ABSTRACT:
Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a PH domain and a PH domain binding partner.
REFERENCES:
Cifuentes et al., J. Biol Chem., vol. 269: 1945-1948, Jan. 1994.
Cifuentes et al., J. Biol. Chem., vol. 268: 11586-11593, Jun. 1993.
Shimohama et al., Neuroscience Letters, vol. 162: 183-186, May 1993.
Lee et al., Current Opinion in Cell Biology, vol. 7: 183-189, Feb. 1995.
Kato et al., J. Biol. Chem., 267:6483-6487, May 1992.
Harlan et al. Nature vol. 371:168-170, Sep. 1994.
Frech, "High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity," J. Biological Chemistry 272(13):8474-8481 (1997).
Pitcher, "Pleckstrin Homology Domain-mediated Membrane Association and Activation of the .beta.-Adrenergic Receptor Kinase Requires Coordinate Interaction with G.beta..gamma. Subunits and Lipid," J. Biological Chemistry 270(20):11707-11710 (1995).
Yao, "Interactions Between Protein Kinase C and Pleckstrin Homology Domains," J. Biological Chemistry, 272(20):13033-13039 (1997).
Ferguson Kathryn M.
Lemmon Mark A.
Schlessinger Joseph
Sigler Paul B.
Chan Christina Y.
Nolan Patrick
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