Methods for diagnosing human influenza and 4-position modified c

Details Methods for diagnosing human influenza and 4-position modified c Methods for diagnosing human influenza and 4-position modified c

1994-12-13

1997-09-02

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 5, 435 84, 435201, 536 184, C12Q 134, C12Q 170, C12N 926

Patent

active

056630557

ABSTRACT:
Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position to contain a hydrogen atom, a fluorine atom, a methoxy group, or an ethoxy group are used as substrates in colorimetric assays for human influenza neuraminidase activity in clinical specimens for the purpose of selectively diagnosing influenza infection. The substrates may exhibit different reactivity with the different types of influenza neuraminidases, thus enabling one to discern the specific type of influenza infection and prescribe appropriate treatment and/or supportive therapy therefor.

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