Methods for diagnosing and treating neuroendocrine cancer

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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07842468

ABSTRACT:
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.

REFERENCES:
patent: 6797692 (2004-09-01), Ikonomidou
patent: 6896872 (2005-05-01), Dambinova
Aparicio-Legarza et al (Neuroscience Letters, Jan. 1998, 241(2-3): abstract).
Aparicio-Legarza et al (Neuroscience Letters, Jan. 1998, 241(2-3):143-146).
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Kinkelin et al (Neuroscience Letters, 2000, 283: 149-152).
Dickman et al (AM J Respir Cell Mol Biol, Feb. 2004, 30(2): 139-144).
Choi et al., “The expression of NMDA receptor 1 is associated with clinicopathological parameters and prognosis in the oral squamous cell carcinoma”, J Oral Patho Med 2004 33:533-537.
North et al., “Presence of Functional NMDA Receptors in a Human Neuroblastoma Cell Line”, Molecular and Chemical Neuropathology 1997 30:77-94.
Rzeski et al., “Glutamate antagonists limit tumor growth”, Biochemical Pharmacology 2002 64:1195-1200.
Markert et al., “Differential gene expression profiling in human brain tumors”, Physiol Genomics 2001 5:21-33.

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