Methods for diagnosing a gastrointestinal disorder in an...

Chemistry: analytical and immunological testing – Biological cellular material tested

Reexamination Certificate

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C436S086000

Reexamination Certificate

active

07575927

ABSTRACT:
Methods for measuring at least one mucosally released neuroendocrine gut system component in an individual and methods for diagnosing a gastrointestinal disorder in an individual based on the concentration of at least one mucosally released neuroendocrine gut system component, and/or the ratio of the concentrations of at least one mucosally released neuroendocrine gut system component and at least one mucosally released inflammatory release mediator are provided.

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patent: 6576429 (2003-06-01), Hallgren
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Yamamoto, Hitoshi et al, “Abnormal Neuropeptide Concentration in Rectal Mucosa of Patients With Inflammatory Bowel Disease,” J. Gastrointestinal, 1996, vol. 31, pp. 525-532.
Coates, Matthew D., et al, “Molecular Defects in Mucosal Serotonin Content and Decreased Serotonin Reuptake Transporter in Ulcerative Colitis and Irritable Bowel Syndrome,” Gastroenterology, 2004; 126:1657-1684/.
Kristjansson, G. et al, “Clinical and Subclinical Intestinal Inflammation Assessed By the Mucosal Patch Technique: Studies of Mucosal Neutrophil Disease and Irritable Bowel Syndrome,” Gut. 2004, vol. 53, pp. 1806-1812.
Carlson, M. et al, “Increased Intraluminal Release of Eosinophil Granule Proteins EPO, ECP, EPX and Cytokines in Ulcerative Colitis and Proctitis in Segmental Perfusion,” The American Journal of Gastroenterology, 1989, vol. 94, No. 7, pp. 1876-1883.

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