Methods for diagnosing a bipolar disorder and unipolar disorder

Details Methods for diagnosing a bipolar disorder and unipolar disorder Methods for diagnosing a bipolar disorder and unipolar disorder

2004-04-14

2008-09-16

Lankford, Blaine (Department: 1651)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S029000, C435S366000, C424S009100, C424S093100, C424S093700, C702S019000

Reexamination Certificate

active

07425410

ABSTRACT:
Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for a bipolar disorder. The diagnostic assay may also or instead exploit the similarity of cells from bipolar patients to those of people already known to have a bipolar disorder. A similar diagnostic assay is provided for diagnosing unipolar disorder. The diagnostic assays may further involve manipulation of membrane potential by incubation of cells in K+-free buffer and/or incubation with one or more compounds that alter Na+K+ ATPase activity. Although a variety of cells may be used, the diagnostic assays preferably employ lymphoblasts or whole blood cells.

REFERENCES:
Cloning: Present Uses and Promises. http://ospp.od.nih.gov/policy/cloning.asp (p. 3, lines1-2).
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El-Mallakh et al. Leukocyte transmembrane potential in bipolar illness. J Affect Disord. Nov. 4, 1996;41(1):33-7.
De Fusco et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. Feb. 2003;33(2):192-6. Epub Jan. 21, 2003.
El-Mallakh et al. (1996) Leukocyte transmembrane potential in bipolar illness. J. Affect. Disord. 41:33-34.
Garrahan et al. 1967. The Behaviour of the Sodium Pump in Red Cells in the Absence of External Potassium. J. Physiol. 192:159-174.
Antia et al. 1995. The upregulation of Na+, K+-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate. J. Affect. Disord. 34:33-39.

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