Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-10-28
1997-10-07
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 74, 436506, 436518, G01N 33564, G01N 33567
Patent
active
056746920
ABSTRACT:
Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic .beta.-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
REFERENCES:
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Rabin et al., Cloning and Expression of IDDM-Specific Human Autoantigen Diabetes 41:183-186, 1992.
Baekkeskov et al., Autoantibodies in Newly Diagnosed Diabetic Children Immunopreciptate Human Pancreatic Islet Cell Proteins. Nature 298: 167-169, 1982.
Aanstoot et al. "Humoral and cellular response to a 38kD islet cell autoantigen in type-1 diabetes," Diabetes 40 Supp. 1 Abstract 898, p. 225A (1991).
Baekkeskov et al. "Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase," Nature 347:151-156 (1990).
Christie et al., "Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment," J. Exp. Med., 172:789-794 (1990).
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Sei.beta.ler et al., "Antibodies to the M.sub.r 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk impaired Beta-cell function," Diabetologia 35:550-554 (1992).
Arden et al., Imogen 38: A Novel 38-kD Islet Mitochondrial Autoantigen Recognized by T Cells from a Newly Diagnosed Type 1 Diabetic Patient, J. Clin. Invest. 97:551-561, 1996.
I.Y. Ko et al., Studies on autoimmunity for initiation of Beta-cell destruction VIII. Pancreatic Beta-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats, Diabetologia 34:548-554, 1991.
S. Baekkeskov et al., Antibodies to an Mr 64,000 Human Islet Cell Protein in the Prediabetic Period of IDDM Patients, Ann. N.Y. Acad. Sci. 475:415-417, 1986.
Aanstoot Henk-Jan
Baekkeskov Steinunn
Knode Marian C.
Wortman Donna C.
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