Methods for determining the potency, specificity, and...

Details Methods for determining the potency, specificity, and... Methods for determining the potency, specificity, and...

2006-11-07

2006-11-07

Tate, Christopher R. (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

Reexamination Certificate

active

07132256

ABSTRACT:
Methods of determining the potency, specificity, and toxicity of microsomal prostaglandin E2 synthase inhibitors are provided that utilize one cell-based assay system.

REFERENCES:
Thoren et al, “Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells (Inhibition by NS-398 and leukotriene C4),” (Eur. J. Biochem.) 2000 vol. 267, pp. 6428-6434.

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