Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1997-01-24
1998-11-24
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4353201, 435348, 4352523, 4352551, 536 235, 935 22, 935 69, 935 70, 935 72, C12N 500, C12N 1500
Patent
active
058405780
ABSTRACT:
A DNA sequence encoding the .delta.-amino levulinate type 2 gene, methods to detect the gene, diagnostic kits to detect the gene and recombinant vectors containing the type 2 gene sequence.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
Wetmur J.G., et al., "Molecular Characteristization of the Human .delta.-nolevulinate Dehydratase 2 (ALAD.sup.2) Allele: Implications for Molecular Screening of Individuals for Genetic Susceptibility to Lead Poisoning", Am.J.Hum.Genet. (1991), 49:757.
Wong et al., "Branch Capture Reactions: Displacers Derived From Asymmetric PCR", Nucleic Acids Res., (1991) 19:9, p. 2251.
Bishop T.R., et al., "Nucleotide Sequence of Rat Liver .delta.-aminolevulinic Dehydratase cDNA", Nucleic Acids Res., (1986), 14, 24:10115.
Bishop T.R., et al., "Cloning and Sequence of Mouse erythroid .delta.-aminolevulinate Dehydratase cDNA", Nucleic Acids Res., (1989), 17, 4:1775.
Chisolm J.J. Jr. et al., "Erythrocyte Porphobilinogen Synthase Activity as an Indicator of Lead Exposure in Children", Clin. Chem., (1985), 31, 4:601.
Claudio L., et al., "Increased Vesicular Transport and Decreased Mitochondrial Content in Blood-Brain Barrier Endothelial Cells During Experimental Autoimmune Encephalomyelitis", Amer.J.Path., (1989), 135, 6:1157.
Jaffe E.K., et al., "Reevaluation of a Sensitive Indicator of Early Lead Exposure", Biol.Trace Element Res., (1991), 28:223.
Seppalainen et al., "Early Neurotoxic Effects of Occupational Lead Exposure: A Prospective Study", NeuroToxicology, (1983), 4:181.
Needleman et al., "Deficits in Psychologic and Classroom Performance of Children With Elevated Dentine Lead Levels", N.Engl.J.Med., (1979), 300:689.
Baker et al., "Occupational Lead Neurotoxicity: Improvement in Behavioural Effects After Reduction of Exposure", Brit.J.Industr.Med., (1985), 42:507.
Jeyaratnam et al., "Neuropsychological Studies on Lead Workers in Singapore", Brit.J.Industr.Med., (1986), 43:626.
Lilis et al., "Effects of Low-Level Lead and Arsenic Exposure on Copper Smelter Workers", Arch.Env.Health, (1985), 40:38.
Winneke et al., "Neuropsychological Comparison of Children With Different Tooth-Lead Levels. Preliminary Report", Internat.Conf. on Heavy Metals in the Environment, Geneva, World Health Organization, (1981), pp. 553-556.
Smith et al., "The Effects of Lead Exposure on Urban Children: The Institute of Child Health/Southampton Study", Dev.Med.Child.Neurol., (1983), 47:1.
Bellinger et al., "Longitudinal Analyses of Prenatal and Postnatal Lead Exposure and Early Cognitive Development", N.Engl.J.Med., (1987), 316:1037.
Gerber et al., "Toxicity, Mutagenicity and Teratogenicity of Lead", Muta.Res., (1980), 76:115.
Wibberley et al., "Lead Levels in Human Placentae from Normal and Malformed Births", J.Med.Genet., (1977), 14:339.
Needleman et al., "The Relationship Between Prenatal Exposure to Lead and Congenital Anomalies", J.Amer.Med.Assoc., (1984), 251:2956.
Deknudt et al., "Chromosome Aberrations Observed in Male Workers Occupationally Exposed to Lead", Environ.Physiol.Biochem., (1973), 3:132.
Wu et al., "The Quaternary Structure of .delta.-Aminolevulinic Acid Dehydratase from Bovine Liver", Proc.Natl.Acad.Sci. USA, (1974), 71:1767.
Gurne et al., "Dissociation and Reassociation of Immobilized Porphobilinogen Synthase: Use of Immobilized Subunits for Enzyme Isolation", Proc.Natl.Acad.Sci. USA, (1977), 74:1383.
Anderson and Desnick, "Purification and Properties of .delta.-Aminolevulinate Dehydrase from Human Erythrocytes", J.Biol.Chem., (1979), 254:6924.
Bevan et al., "Mechanism of Porphobilinogen Synthase", J.Biol.Chem., (1980), 255:2030.
Tsukamoto et al., "The Role of Zinc With Special Reference to the Essential Thiol Groups in .delta.-aminolevulinic Acid Dehydratase of Bovine Liver", Biochem.Biophys.Acta, (1979), 570:167.
Tsukamoto et al., "Zinc and Cysteine Residues in the Active Site of Bovine Liver .delta.-aminolevulinic Acid Dehydratase", Int.J.Biochem., (1980), 12:751.
Jaffe et al., "Porphobilinogen Synthase Modification with Methylmethanethiosulfonate", J.Biol.Chem., (1984), 259:5032.
Jordan et al., "Mechanism of Action of 5-aminolaevulinate Deshydratase from Human Erythrocytes", Biochem.J., 227:1015.
Morgan and Burch, "Comparative Tests for Diagnosis of Lead Poisoning", Arch.Intern.Med., (1972), 130:335.
Chisholm et al., "Chronic Lead Intoxication in Children", Dev.Med.Child.Neurol., (1965), 7:529.
Petrucci et al., "The Genetic Polymorphism of Delta-aminolaevulinate Deshydrase in Italy", Hum.Genet., (1982), 60:289.
Battistuzzi et al., ".delta.-aminolaevulinate Deshydrase: A New Genetic Polymorphism in Man", Ann.Hum.Genet., (1981), 45:223.
Potluri et al., "Human .delta.-aminolaevulinate Deshydratase: Chromosomal Localization to 9q34 by In Situ Hybridization", Hum.Genet., (1987), 76:236.
Benkmann et al., Polymorphism of Delta-Aminolevulinic Acid Dehydratase in Various Populations, Hum.Hered., (1983), 33:62.
Propping, "Pharmacogenetics", J.Physiol.Biochem.Pharmacol., (1978), 83:124.
Ziemsen et al., "Polymorphism of Delta-aminolevulinic Acid Dehydratase in Lead-Exposed Workers", Int.Arch.Occup.Environ.Health, (1986), 58:245.
Ben-Ezzer et al., "Genetic Polymorphism of Delta-Aminolevulinate Dehydrase In Several Population Groups in Israel", Hum.Hered., (1987), 37:229.
Connor et al., "Detection of Sickle Cell .beta..sup.s -Globin Allele by Hybridization with Synthetic Oligonucleotides", Proc.Natl.Acad.Sci. USA, (1983), 80:278.
Saiki et al., "Analysis of Enzymatically Amplified .beta.-Globin and HLA-DQ.sub..alpha. DNA with Allele-Specific Oligonucleotide Probes", Nature, (1986), 324:163.
Chehab et al., "Detection of Sickle Cell Anaemia and Thalassaemias", Nature, (1987), 329:293.
Landegren et al., "A Ligase-Mediated Gene Detection Technique", Science, (1988), 241:1077.
Wu et al., "Allele-Specific Enzymatic Amplification of .beta.-Globin Genomic DNA for Diagnosis of Sickle Cell Anemia", (1989), Proc.Natl.Acad.Sci.USA, (1989), 86:2757.
Wu et Wallace, "The Ligation Amplification Reaction (LAR)--Amplifaction of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation", Genomics, (1989), 4:560.
Gordon and Ruddle, "Gene Transfer into Mouse Embryos: Production of Transgenic Mice by Pronuclear Injection", Methods Enzymol., (1983), 101:411.
Southern, "Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis", J.Mol.Biol., (1975), 98:503.
Saiki et al., "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase", Science (1988), 239:487.
Botstein et al., "Construction of a Genetic Linkage Map in Man Using Restriction Fragment Length Polymorphisms", Am.J.Hum.Genet., (1980), 32:314.
Pasvol et al., "Cellular Mechanism for the Protective Effect of Haemoglobin S. Against P. falciparum Malaria", Nature, (1978), 274:7801.
Astrin et al., ".delta.-Aminolevulinic Acid Deshydratase Isozymes and Lead Toxicity", Ann.N.Y.Acad.Sci., (1987), 514:23.
Wetmur et al., "Human .delta.-aminolevulinate Deshydratase: Nucleotide Sequence of a Full-length cDNA Clone", Proc.Natl.Acad.Sci. USA, (1986), 83:7703.
Chirgwin et al., "Isolation of Biologically Active Ribonucleic Acid From Sources Enriched in Ribonuclease", Biochem., (1979), 18:5294.
Kushner et al., "An Improved Method for Transformation of Escherichia coli with ColE1 Derived Plasmids", Genetic Engineering, Boyer Nicosia, eds. Elsevier/North-Holland Biomedical Press, Amsterdam, (1978), pp. 17-23.
Wetmur J.G., et al., "The .delta.-aminolevulinate Dehydratase Polymorphism: Higher Blood Lead Levels in Lead Workers and Environmentally Exposed Children with the 1-2 and 2-2 Isozymes", Environ. Res., (1991), 56:109.
Wetmur et al PNAS 83:7703, 1986.
Wetmur et al Am. J. Human Genetics 49:757, 1991.
Palmuter et al Am. Rev. Genet. 20:465, 1986.
Desnick Robert J.
Wetmur James G.
Campell Bruce R.
Mount Sinai School of Medicine of the City University of New Yor
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