Methods for determining renal toxins

Details Methods for determining renal toxins Methods for determining renal toxins

2005-01-18

2008-09-16

Smith, Carolyn L. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C435S006120, C700S030000, C702S022000, C707S793000

Reexamination Certificate

active

07426441

ABSTRACT:
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

REFERENCES:
patent: 5811231 (1998-09-01), Farr et al.
patent: 5858659 (1999-01-01), Sapolsky et al.
patent: 5953727 (1999-09-01), Maslyn et al.
patent: 5965352 (1999-10-01), Stoughton et al.
patent: 6132969 (2000-10-01), Stoughton et al.
patent: 6153421 (2000-11-01), Yanagi et al.
patent: 6160105 (2000-12-01), Cunningham et al.
patent: 6185561 (2001-02-01), Balaban et al.
patent: 6203987 (2001-03-01), Friend et al.
patent: 6218122 (2001-04-01), Friend et al.
patent: 6228589 (2001-05-01), Brenner
patent: 6229911 (2001-05-01), Balaban et al.
patent: 6365352 (2002-04-01), Yerramilli et al.
patent: 6372431 (2002-04-01), Cunningham et al.
patent: 6403778 (2002-06-01), Cunningham et al.
patent: 6421612 (2002-07-01), Agrafiotis et al.
patent: 6461807 (2002-10-01), Friend et al.
patent: 2001/0039006 (2001-11-01), Snodgrass
patent: 2001/0049139 (2001-12-01), Lagasse et al.
patent: 2002/0119462 (2002-08-01), Mendrick et al.
patent: 2002/0142284 (2002-10-01), Raha et al.
patent: 2003/0028327 (2003-02-01), Brunner et al.
patent: 2003/0124552 (2003-07-01), Lindemann et al.
patent: 2003/0154032 (2003-08-01), Pittman et al.
patent: WO 93/01205 (1993-01-01), None
patent: WO 94/17208 (1994-04-01), None
patent: WO 95/11755 (1995-05-01), None
patent: WO 97/13877 (1997-04-01), None
patent: WO 97/16732 (1997-05-01), None
patent: WO 99/12118 (1999-03-01), None
patent: WO 99/27090 (1999-06-01), None
patent: WO 99/32660 (1999-07-01), None
patent: WO 99/43345 (1999-09-01), None
patent: WO 99/58670 (1999-11-01), None
patent: WO 00/28092 (2000-05-01), None
patent: WO 00/39336 (2000-07-01), None
patent: WO 00/47761 (2000-08-01), None
patent: WO 00/12760 (2000-09-01), None
patent: WO 00/63435 (2000-10-01), None
patent: WO 01/02609 (2001-01-01), None
patent: WO 01/11076 (2001-02-01), None
patent: WO 01/14425 (2001-03-01), None
patent: WO 01/20043 (2001-03-01), None
patent: WO 01/23886 (2001-04-01), None
patent: WO 01/25473 (2001-04-01), None
patent: WO 01/32928 (2001-05-01), None
patent: WO 01/36684 (2001-05-01), None
patent: WO 01/38579 (2001-05-01), None
patent: WO 01/44512 (2001-06-01), None
patent: WO 01/63279 (2001-08-01), None
patent: WO 02/31704 (2002-04-01), None
patent: WO 03/085083 (2003-10-01), None
patent: WO 03/095624 (2003-11-01), None
patent: WO 03/100030 (2003-12-01), None
“nephrotoxic” definition, Merriam-Webster online dictionary, 2005, on the world wide web at http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=nephrotoxic, 2 pages.
Aardema and MacGregor, Mutation Res., 499:13-25, (2002).
Adamson & Harman et al., Biochem. Pharmacol., 45:2289-2294 (1993).
Affymetrix Rat Toxicology U34 Datasheet, released Aug. 1999.
Afshari et al., Cancer Res., 59: 4759-4760 (1999).
Agha et al., Lipid Peroxidation and Lysosomal Integrity ; 31., 279-285 (1995).
Ahotupa et al., Carcinogenesis., 15: 863-868 (1994).
Ala-Kokko et al., Biochem. J., 244:75-79, (1987).
Al-Bayati & Stohs, Arch. Environ. Contam. Toxicol., 20:361-365 (1991).
Allan et al., J. Biol. Chem.., 276: 27272-27280 (2001).
Amelsen, Jean Claude., Setting death in motion , vol. 395, (1998).
Anderson & Barton, Environ. Health Perspect., 106: 349-355 (1998).
Anderson et al., Toxicol. Appl. Pharmacol., 137: 75-89 (1996).
Anderson, Steven P., Hepatic Expression of Acute-Phase Protein, 26: 226-238 (1999).
Andersson et al; Anthraquinone-induced cell injury; 135: 11-20 (1999).
Anton et al., Cell Biochem. Biophys., 32: 27-36 (2000) Abstract only.
Arano et al ., Arzneim-Forsch./Drug, 46 : 398-400 (1996).
Atchinson et al., Digestive Dis. Sci., 45: 614-620 (2000).
Bajgar et al., Neurochem. Int., 24: 555-558 (1994).
Baker et al., Chem. Res. Toxicol., 14(9): 1218-1231 (2001)
Bandara, et al., Toxicol. Sci., 73:195-206, (2003).
Barner & Gray, Ann. Pharmacother., 32: 70-77 (1998).
Bartosiewicz et al., J. Pharmacol. Exp. Ther., 297: 895-905 (2001).
Beck et al, Arch. Toxicol., 64: 210-217 (1990).
Becker et al., Alzheimer Dis. Assoc. Disord., 10 : 124-131 (1996).
Bedard et al., Antimicrob. Agents Chemother., 43: 557-567 (1999).
Bedossa et al., Hepatology, 19: 1262-1271 (1994).
Beierschmitt, William P., Induction of Hepatic Microsomal Drug-Metabolizing;, 15-21, 2001.
Belury et al., Toxicol. Appl. Pharmacol., 151: 254-261 (1998).
Berbner et al., “induction of cytochrome P450 IA and NDA damage in isolated rainbow trout (Onchorhynchus mykiss) hepatocytes by 2, 3, 7, 8-tetrachlorodibenzo p-dioxin,” Biomarkers 4: 214-228 (1999).
Bergeron et al., Xenobiotica, 28: 303-312 (1998).
Berndt et al., Proc. Natl. Acad. Sci. U.S.A.., 95: 12556-12561 (1998).
Birge et al., Toxicol. Appl. Pharmacol., 105: 472-482 (1990).
Bissig et al., “Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes,” J Biol Chem 269(4):3017-3021, 1994.
Boelsterli et al., Cell Biol, Toxicol., 3: 231-250 (1987).
Boess, et al., Toxicological Sciences, 73:386-402, (2003).
Bogdan, “Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protien BTG1,”Biochem. J. 336:471-481 (1998).
Boon, et al., Proc. Natl. Acad. Sci. USA, 99(17):11287-11292, (2002).
Boorman et al., “Toxicogenomics, Drug Discovery, and the Pathologist,” Toxicologic Pathology 30(1): 15-27 (2002).
Bort et al., J. Pharmacol. Exp. Ther., 288: 65-72 (1999).
Bosio and Borlak, Innovations in Pharmaceutical Technology, 65-75, 2001.
Bouchard et al., Liver, 13: 193-202 (1993).
Bramow, Stephan, et al., Pharmacol. & Toxicol., 89:133-139, (2001).
Browne, et al., Targets, 1(2):59-65, (2002).
Bruck et al., Dig. Dis. Sci., 44: 1228-1235 (1999).
Bulera, S.J., et al., Hepatology, 33:1239-1258, (2001).
Burchiel et al., Toxicol. Sci., 59: 193-195 (2001).
Burczynski & Penning, Cancer Res., 60: 908-915 (2000) Abstract only.
Burczynski (Editor), “An Introduction to Toxicogenomics,” Wyeth Research, Andover, MA, CRC Press pp. 226-259, (Pub. 2003).
Burczynski et al., Toxicol. Sci., 58:399-415 (2000).
Burris, Hicken and Farr, Genetic Engineering News, May 1, 1999, pp. 42-43, (1999).
Bursch et al., Arch. Toxicol., 69: 253-258 (1995).
Buttar et al., Toxicology., 6: 9-20 (1976).
Butterworth et al., Cancer Res., 49: 1075-1084 (1989).
Cadet, et al., Synapset, 44:211-226 (2002).
Cai et al., J. Med. Chem., 41: 1970-1979 (1998).
Calabrese et al., J. Amer. College Toxicol., 15: 62-69 (1996).
Castell et al., Cell Biol. Toxicol., 13: 331-338 (1997).
Castle, A., et al., “Apex Necrosis,” Soc. Of Tox. Mtg. (2004).
Castle, A., et al., “Effects of Multiple Cardiac Apex Necrosis Agents on Genome Wide Expression,” Soc. Of Tox. Mtg. (2003) Abstract only.
Castle, A.L., et al., “Liver Toxicity Prediction and Classification Using Microarray Data: . . . ,” Soc. Of. Tox. Mtg., (2002).
Castle, Carver & Mendrick, Drug Disc. Today, 7(13):728-736, (2002).
Chan et al., Proc. Natl. Acad. Sci. U.S.A.., 98: 4611-4616 (2001).
Chanda et al., Hepatology, 21: 477-486 (1995).
Chen et al., J. Biol. Chem.., 275: 22619-22622 (2000).
Chen et al., J. Environ. Pathol. Toxicol. Oncol., 14: 83-99 (1995) Abstract only.
Chen, et al., Mol. Carcinog. 30:79-87, (2001).
Chisholm et al., Am. J. Physiol., 276: G1165-G1173 (1999).
Chou et al., Proc. Natl. Acad. Sci. U.S.A.., 98: 8113-8118 (2001).
Christian et al., Toxicol. Appl. Pharmacol., 82: 239-255 (1986).
Clive et al., Fundam. Appl. Toxicol., 3: 587-602 (1983).
Coles et al., Arch. Biochem. Biophys., 264: 253-260 (1988).
Conforti et al., Agents Actions, 40: 176-180 (1993).
Coni et al., Hepatology, 17: 1109-1116 (1993).
Copenhagen et

Affiliated with

Also associated with

Rating

Methods for determining renal toxins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for determining renal toxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for determining renal toxins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3980731