Methods for determining platelet function

Details Methods for determining platelet function Methods for determining platelet function

1995-05-03

1999-09-14

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 435 13, 436503, 436533, 436534, G01N 33546, G01N 33547, G01N 33567, C12Q 156

Patent

active

059521848

ABSTRACT:
The invention provides a method for determining platelet function in a mammal comprising providing platelets from the mammal, contacting the platelets in suspension with at least one immobilised ECM protein or an effective fragment or analog thereof while applying to the platelets an effective mechanical stimulus for an effective period of time and determining the platelet activation produced.
The invention provides a method for monitoring the efficacy of pharmacological agents affecting platelet function in vivo and in vitro.

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