Methods for determining enantiomeric purity

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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C702S023000

Reexamination Certificate

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11004597

ABSTRACT:
A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.

REFERENCES:
patent: 5989916 (1999-11-01), Purdie
patent: 6922645 (2005-07-01), Haaland et al.
patent: 6934638 (2005-08-01), Ito et al.
patent: 2002/0103232 (2002-08-01), Whittle et al.
Balabai, et al., Orientational Dynamics of B-Cyclodextrin Inclusion Complexes, J. Phys. Chem. B 1998, 102, pp. 9617-9624.
Bortolus, et al., Chiral Discrimination of Camphorquinone Enantiomers by Cyclodextrins, J. Phys. Chem. A 2002, 106, pp. 1686-1694.
Cox, et al., Dialkylaminobenzonitriles as Fluorescence Polarity Probes for Aqueous Solutions . . . , J. Photochem. Photobiol. 1984, 39(5), pp. 597-601.
Dotsikas, et al., Interaction of 6-p-toluidinylnaphthalene-2-sulphonate with B-cyclodextrin, J. Pharm. Biomed. Anal. 2000, 23, pp. 997-1003.
Jiang, et al., Imtramolecular exciplex and cation-mediated charge-transfer fluorescence . . . , J. Chem. Soc., Perkin Trans. 2001, 2, pp. 1274-1279.
Martens, et al., Multivariate Calibration, 1989, John Wiley & Sons, Chichester, Great Britain.
Otagiri, et al., Inclusion complexes of B-Cyclodextrin with Tranquilizing Drugs Phenothiazines . . . , Chem. Pharm. Bull. 1975, 23, pp. 188-195.
Schiller, et al., The Inclusion of Pyronine by B- and y-Cyclodextrin, J. Schem. Soc., Faraday Trans. 1987, 83(11), pp. 3237-3248.
Smith, et al., Spectroscopic Study of the Interaction of Catechin with a-, B-, and y-Cyclodextrins, J. Phys. Chem. 1994, 98, pp. 8627-8631.
Sullivan, G.R., Chiral Lanthanide Shift Reagents, Top. Stereochem. 1978, 10, pp. 287-329.
Suzuki, H., Electronic Absorption Spectra and Geometry of Organic Molecules, 1967, pp. 102-105, Academic Press, New York, NY.
Park, et al., Excited-State Proton Transfer of 2-Naphthol Inclusion Complexes with Cyclodextrins, J. Phys. Chem. 1994, 98, pp. 6158-6199.
Busch KW, Swamidoss IM, Fakayode SO, Busch MA. Determination of the enantiomeric composition of guest molecules by chemometric analysis of the UV-visible spectra of cyclodextrin guest-host complexes. J Am Chem Soc. Feb. 19, 2003; 125(7):1690-1
Haglund P. Enantioselective Separation of Polychlorinated Biphenyl Atropisomers Using Chiral High-Performance Liquid Chromatography. J of Chromatography A, Elsevier, Amsterdam, NL. Feb. 16, 1996;724(1):219-228.
Louka YL, Sabbah S, Scriba GK. Method development and validation for the chiral separation of peptides in the presence of cyclodextrins using capillary electrophoresis and experimental design. J Chromatogr A. Oct. 5, 2001;931(1-2):141-52.
Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration from the PCT dated Jun. 1, 2006.

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