Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-02
1999-11-23
Teng, Sally
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 691, 4352523, 43525411, 435325, 530350, C12Q 102, C12N 1512, C07K 14705
Patent
active
059898330
ABSTRACT:
Polypeptide of a growth factor receptor family, having a specific sequence and presenting all or part of the following properties: it encourages and/or is involved in the proliferation and/or differentiation of hematopoietic cell lines when obtained from the MPLV retrovirus; it is capable of acting as a hematopoietic growth factor receptor; it is recognized by antibodies directed against it. Polypeptides similar to the above. Applications in the diagnosis of the expression of said ligand polypeptide.
REFERENCES:
Le Coniat, M. et al., 1989, "The human homolog of the myeloproliferative us maps to chromosome band 1p34, " Hum. Genetics 83:194-196.
Wending, F. et al., 1990, "Myeloproliferative leukemia virus sustains proliferation and differentiation of hematopoietic progenitor cells, " Exp. Hematol. 18:624.
Wendling, F. et al., 1989, "Myeloid progenitor cells transformed by the myeloproliferative leukemia virus proliferate and differentiate in vitro without the addition of growth factors," Leukemia 3:475-480.
Wendling, F. et al., 1989, "Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus," Blood 73:1161-1167.
Wendling, F. et al., 1986, "MPLV: a retrovirus complex inducing an acute myeloroliferative leukemic disorder in adult mice," Virology 149: 242-246.
Benit et al., "The 'WS motif" Common to v-mpl and Members of the Cytokine Receptor Superfamily is Dispensable for Myeloproliferative Leukemia Virus Pathogenicity , Onogene, 8:787-790 (1993) (no. month available on reference).
Penciolelli et al., "Genetic Analysis of Myeloproliferative Leukemia Virus, a Novel Acute Leukemogenic Replication-Defective Retrovirus", J. Virology, 61:579-583 (Feb. 1987).
Skoda et al., "Murine c-mpl: a Member of the Hematopoietic Growth Factor Receptor Superfamily that Transduces a Proliferative Signal", The EMBO Journal, 12:2645-2653 (1993) (no month available on reference).
Souyri et al., "A Putative Truncated Cytokine Receptor Gene Transduced by the Myeloproliferative Leukemia Virus Immortalizes Hematopoietic Progenitors", Cell, 63:000-000 (Dec. 21, 1990).
Souyri et al., "A Putative Truncated Cytokine Receptor Gene Transduced by the Myeloproliferative Leukemia Virus Immortalizes Hematopoietic Progentiors", Cell, 63:1137-1147 (Dec. 21, 1990).
Vigon et al., "Molecular Cloning and Characterization of MPL, the Human Homolog of the v-mpl Oncogene: Identification of a Member of the Hematopietic Growth Factor Receptor Superfamily", Proc. Natl. Acad. Sci. USA), 89:5640-5644 (Jun. 1992).
Vigon et al., "Characterization of the Murine Mpl proto-oncogene, a Member of the Hematopoietic Cytkine Receptor Family: Molecular Cloning, Chromosomal Location and Evidence for a Function in Cell Growth", Oncogene, 8:2607-2615 (1993) (no month available on reference).
Charon Martine
Gisselbrecht Sylvie
Penciolelli Jean-Francios
Souyri Michele
Tambourin Pierre
Institut National de la Sante et de la Recherche Medicale (Inser
Teng Sally
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