Methods for detection of genetic disorders

Details Methods for detection of genetic disorders Methods for detection of genetic disorders

2005-08-26

2008-10-28

Whisenant, Ethan (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S022100

Reexamination Certificate

active

07442506

ABSTRACT:
The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.

REFERENCES:
patent: 4521509 (1985-06-01), Benkovic et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4889818 (1989-12-01), Gelfand et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4994372 (1991-02-01), Tabor et al.
patent: 5023171 (1991-06-01), Ho et al.
patent: 5066584 (1991-11-01), Gyllensten et al.
patent: 5075216 (1991-12-01), Innis et al.
patent: 5079352 (1992-01-01), Gelfand et al.
patent: 5091310 (1992-02-01), Innis
patent: 5098839 (1992-03-01), Polisson
patent: 5104792 (1992-04-01), Silver et al.
patent: 5153117 (1992-10-01), Simons
patent: 5326857 (1994-07-01), Yamamoto et al.
patent: 5426026 (1995-06-01), Jordan
patent: 5432054 (1995-07-01), Saunders et al.
patent: 5501963 (1996-03-01), Burckhardt et al.
patent: 5538848 (1996-07-01), Livak et al.
patent: 5538871 (1996-07-01), Nuovo et al.
patent: 5545552 (1996-08-01), Mathur
patent: 5565339 (1996-10-01), Bloch et al.
patent: 5576176 (1996-11-01), Adams et al.
patent: 5582989 (1996-12-01), Caskey et al.
patent: 5618664 (1997-04-01), Kiessling
patent: 5631147 (1997-05-01), Lohman et al.
patent: 5635348 (1997-06-01), Leong
patent: 5639611 (1997-06-01), Wallace et al.
patent: 5641628 (1997-06-01), Bianchi
patent: 5648222 (1997-07-01), Tse et al.
patent: 5693469 (1997-12-01), Hogan
patent: 5723591 (1998-03-01), Livak et al.
patent: 5744301 (1998-04-01), Birkenbach et al.
patent: 5759772 (1998-06-01), Kirkpatrick et al.
patent: 5817797 (1998-10-01), Mitchell et al.
patent: 5831065 (1998-11-01), Brenner et al.
patent: 5858671 (1999-01-01), Jones
patent: 5882857 (1999-03-01), Western et al.
patent: 5965363 (1999-10-01), Monforte et al.
patent: 5985260 (1999-11-01), Shanbrom
patent: 5998141 (1999-12-01), Acton
patent: 6004744 (1999-12-01), Goelet et al.
patent: 6013431 (2000-01-01), Soderlund et al.
patent: 6017699 (2000-01-01), Jordan
patent: 6033861 (2000-03-01), Schafer et al.
patent: 6043031 (2000-03-01), Koster et al.
patent: 6090553 (2000-07-01), Matson
patent: 6100029 (2000-08-01), Lapidus et al.
patent: 6110709 (2000-08-01), Ausubel et al.
patent: 6117679 (2000-09-01), Stemmer
patent: 6124120 (2000-09-01), Lizardi
patent: 6132970 (2000-10-01), Stemmer
patent: 6140054 (2000-10-01), Wittwer et al.
patent: 6153410 (2000-11-01), Arnold et al.
patent: 6156504 (2000-12-01), Gocke et al.
patent: 6156886 (2000-12-01), Sone
patent: 6165793 (2000-12-01), Stemmer
patent: 6174681 (2001-01-01), Halling et al.
patent: 6177263 (2001-01-01), Arnold et al.
patent: 6180372 (2001-01-01), Franzen et al.
patent: 6180406 (2001-01-01), Stemmer
patent: 6183958 (2001-02-01), Stanton, Jr.
patent: 6197563 (2001-03-01), Erlich et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6214558 (2001-04-01), Shuber et al.
patent: 6221600 (2001-04-01), MacLeod et al.
patent: 6225061 (2001-05-01), Becker et al.
patent: 6251639 (2001-06-01), Kurn
patent: 6258540 (2001-07-01), Lo et al.
patent: 6268146 (2001-07-01), Shultz et al.
patent: 6269957 (2001-08-01), Bowers et al.
patent: 6277638 (2001-08-01), Stemmer
patent: 6280949 (2001-08-01), Lizardi
patent: 6287861 (2001-09-01), Stemmer et al.
patent: 6291242 (2001-09-01), Stemmer
patent: 6297053 (2001-10-01), Stemmer
patent: 6323009 (2001-11-01), Lasken et al.
patent: 6323030 (2001-11-01), Stemmer
patent: 6344356 (2002-02-01), Stemmer
patent: 6357601 (2002-03-01), Bowers et al.
patent: 6365375 (2002-04-01), Dietmaier et al.
patent: 6372497 (2002-04-01), Stemmer
patent: 6379896 (2002-04-01), Stanton, Jr.
patent: 6387621 (2002-05-01), Wittwer
patent: 6395547 (2002-05-01), Stemmer
patent: 6413774 (2002-07-01), Stemmer et al.
patent: 6440706 (2002-08-01), Vogelstein et al.
patent: 6444468 (2002-09-01), Stemmer et al.
patent: 6475736 (2002-11-01), Stanton, Jr.
patent: 6506561 (2003-01-01), Cheval et al.
patent: 6506602 (2003-01-01), Stemmer
patent: 6518065 (2003-02-01), Stemmer
patent: 6537746 (2003-03-01), Arnold et al.
patent: 6573098 (2003-06-01), Stemmer
patent: 6573300 (2003-06-01), Chang et al.
patent: 6582906 (2003-06-01), Cao et al.
patent: 6602986 (2003-08-01), Stemmer et al.
patent: 6613517 (2003-09-01), Michelotti
patent: 6617137 (2003-09-01), Dean et al.
patent: 6638722 (2003-10-01), Ji et al.
patent: 6642034 (2003-11-01), Lizardi
patent: 6673541 (2004-01-01), Klein et al.
patent: 6673551 (2004-01-01), Stanton, Jr.
patent: 6703228 (2004-03-01), Landers et al.
patent: 6730517 (2004-05-01), Koster et al.
patent: 6780593 (2004-08-01), Galibert et al.
patent: 6977162 (2005-12-01), Dhallan
patent: 6995841 (2006-02-01), Scott et al.
patent: 7208274 (2007-04-01), Dhallan
patent: 7332277 (2008-02-01), Dhallan
patent: 2001/0051341 (2001-12-01), Lo et al.
patent: 2002/0045176 (2002-04-01), Lo et al.
patent: 2002/0119478 (2002-08-01), Umansky et al.
patent: 2003/0044388 (2003-03-01), Dennis et al.
patent: 2003/0044791 (2003-03-01), Flemington
patent: 2003/0054386 (2003-03-01), Antonarakis et al.
patent: 2003/0082576 (2003-05-01), Jones et al.
patent: 2003/0099964 (2003-05-01), Patil et al.
patent: 2003/0180746 (2003-09-01), Kmiec et al.
patent: 2003/0186239 (2003-10-01), Dhallan
patent: 2003/0232348 (2003-12-01), Jones et al.
patent: 2003/0235834 (2003-12-01), Dunlop et al.
patent: 2004/0106102 (2004-06-01), Dhallan
patent: 2004/0137470 (2004-07-01), Dhallan
patent: 2004/0185495 (2004-09-01), Schueler et al.
patent: 2005/0037388 (2005-02-01), Antonarakis et al.
patent: 2005/0095621 (2005-05-01), Sidranksy
patent: 2005/0260656 (2005-11-01), Dhallan
patent: 2006/0121452 (2006-06-01), Dhallan
patent: 2007/0122835 (2007-05-01), Dhallan
patent: 2007/0178478 (2007-08-01), Dhallan et al.
patent: 2007/0196842 (2007-08-01), Dhallan
patent: 0994963 (2000-04-01), None
patent: 0994963 (2000-04-01), None
patent: 2299166 (1996-09-01), None
patent: 2299166 (1996-09-01), None
patent: WO-91-08304 (1991-06-01), None
patent: WO-95/06137 (1995-03-01), None
patent: WO-98/12355 (1998-03-01), None
patent: WO-98/39474 (1998-09-01), None
patent: WO-99/54498 (1999-10-01), None
patent: WO-01/42504 (2001-06-01), None
patent: WO-01/42504 (2001-06-01), None
patent: WO-02/04672 (2002-01-01), None
patent: WO-02/04672 (2002-01-01), None
patent: WO-02/055985 (2002-07-01), None
patent: WO-02/055985 (2002-07-01), None
patent: WO-02/083839 (2002-10-01), None
patent: WO-02/083839 (2002-10-01), None
patent: WO-03/001181 (2003-01-01), None
patent: WO-03/001181 (2003-01-01), None
patent: WO-03/074723 (2003-09-01), None
patent: WO-03/074723 (2003-09-01), None
patent: WO-03/074740 (2003-09-01), None
patent: WO-03/106642 (2003-12-01), None
patent: WO-03/106642 (2003-12-01), None
patent: WO-2004/058987 (2004-07-01), None
patent: WO-2004/058987 (2004-07-01), None
patent: WO-2004/078994 (2004-09-01), None
patent: WO-2004/078994 (2004-09-01), None
patent: WO-2004/079011 (2004-09-01), None
patent: WO-2007/075836 (2007-07-01), None
Lo et al., Increased Fetal DNA concentrations in the plasma of pregnant women carrying fetuses with Trisomy 21. Clinical Chemistry 45 (10): 1747-1751(1999).
Ahlquist, D. A. et al. (2000). “Colorectal Cancer Screening by Detection of Altered Human DNA in Stool: Feasibility of a Multitarget Assay Panel,”Gastroenterology119:1219-1227.
Amicucci, P. et al. (2000). “Prenatal Diagnosis of Myotonic Dystrophy Using Fetal DNA Obtained from Maternal Plasma,”Clinical Chemistry46(2):301-302.
Angert, R.M. et al. (Jan. 2003). “Fetal Cell-Free Plasma DNA Concentrations in Maternal Blood Are Stable 24 Hours after Col

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