Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2002-09-09
2011-10-04
Swope, Sheridan (Department: 1652)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C435S023000
Reexamination Certificate
active
08029764
ABSTRACT:
Particular genes are aberrantly and consistently expressed in both adenomas and carcinomas of the colon. Products of such genes provide stool and serum markers for colorectal neoplasia. One particular tumor marker, Renal Dipeptidase (RDP), is expressed at high levels in tumors and at greatly reduced levels in normal tissues. The elevated expression of RDP occurs early and remains elevated during the neoplastic process. RDP may therefore be especially useful as a diagnostic tool for the early detection of colorectal neoplasia, even of presymptomatic colorectal neoplasia.
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Buckhaults Phillip
Kinzler Kenneth W.
Vogelstein Bert
Banner & Witcoff , Ltd.
Swope Sheridan
The Johns Hopkins University
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