Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-07-21
1998-12-01
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9151, 436 63, 436 64, 436813, 935 77, 935 78, C12Q 168, C12P 1934
Patent
active
058436421
ABSTRACT:
The present invention provides a method of diagnosing APL in a subject which comprises detecting in a sample from the subject either nucleic acid encoding an abnormal RAR-.alpha. receptor or an expressed protein encoded thereby. The present invention also provides methods of identifying a subject with APL who will or will not respond to treatment with a retinoid, as well as a subjects with APL who do not express a detectable t(15;17) translocation but will or will not respond to treatment with a retinoid. In addition, the present invention provides methods for monitoring the activity of APL and the process of treatment of APL. The present invention provides methods of identifying a subject with a neoplastic condition other than APL who will or will not respond to treatment with a retinoid as well as methods for monitoring the level of disease activity and progress and adequacy of treatment of a neoplastic condition. Lastly, the present invention provides a method for inhibiting the growth of a neoplastic cell.
REFERENCES:
patent: 4681840 (1987-07-01), Stephenson et al.
patent: 4683195 (1987-07-01), Mullis et al.
de The et al (1990) Nature 347: 558-561.
Castaighe et al (1990) 76: 1704-1709, Blood.
Borrow et al Science (1990) 249:1577-1580.
Biondi, A., et al. (1991) RAR-a Gene Rearrangements as a Genetic Marker for Diagnosis and Monitoring in Acute Promyelocytic Leukemia, Blood, vol. 77, No. 7 pp. 1418-1422.
Borrow, J., et al. (1990) Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17. Science, 249:1577-1580.
Chomienne, C., et al. (1990) The Retinoic Acid Receptor a gene is Rearranged in Retinoic Acid-Sensitive Promyelocytic Leukemias. Leukemia, vol. 4, No. 12, pp. 802-807.
de The, et al. (1990) The t(15;17) Translocation of Acute Promyelocytic Leukemia Fuses the Retinoic Acid Receptor a Gene to a Nevel Transcribed Locus. Nature, vol. 347, pp. 558-561.
Kumar, et al. (1989) The Technique of Polymerase Chain Reaction. Technique, 1(3):133-152.
Lemons, R.S., et al. (1990) Cloning and Characterization of the t(15;17) Translocation Breakpoint Region in Acute Promyelocytic Leukemia. Genes, Chromosomes and Cancer, 2:79-87.
Longo, L., et al. (1990) Rearrangements and Aberrant Expression of the Retinoic Acid Receptor a Gene in Acute Promyelocytic Leukemias. J. Exp. Med. 172:1571-1575.
Longo, L., et al. (1990) Mapping of Chromosome 17 breakpoints in Acute Myeloi Leukemias. Oncogne, 5:1557-1563.
Memorial Sloan-Kettering Cancer Center Newsletter, (1991) Pioneering Study Links New Therapy to Gene Damage Site, Center News, pp. 1 and 4.
Miller, Jr., et al. (Dec. 1990) Novel Retinoic Acid Receptor--a Transcripts in Acute Promyelocytic Leukemia Responsive to All-Trans-Retinoic Acid. J. Natl. Cancer Inst., 82(24):1932-1933.
Warrell Jr., et al. (May 16, 1991) Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-Trans-Retinoic Acid). New England Journal of Medicine, 324:1385-1393.
Warrell Jr., et al. (1991) All Trans Retinoic Acid in Acute Promyelocytic Leukemia: Preliminary U.S. Clinical Experience. Blood (Suppl.), 76:334A.
Zabel, B., et al. (1983) High-Resolution Chromosomal Localization of Human Genes for Amylase, Proopiomelanocortin, Somatostatin, and a DNA Fragment (D3sl) by in situ Hybridization. Proc. Natl. Acad. Sci. U.S.A., 80:6932-6936.
Dmitrovsky Ethan
Frankel Stanley
Miller, Jr. Wilson H.
Warrell, Jr. Raymond P.
Myers Carla J.
Sloan-Kettering Institute for Cancer Research
White John P.
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