Methods for detecting vitamin D metabolites

Details Methods for detecting vitamin D metabolites Methods for detecting vitamin D metabolites

2005-04-06

2010-06-29

Warden, Jill (Department: 1797)

Chemistry: analytical and immunological testing

Oxygen containing

Hydroxyl containing

C436S173000

Reexamination Certificate

active

07745226

ABSTRACT:
Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.

REFERENCES:
patent: 5772874 (1998-06-01), Quinn et al.
patent: 5795469 (1998-08-01), Quinn et al.
patent: 5919368 (1999-07-01), Quinn et al.
patent: 5968367 (1999-10-01), Quinn et al.
patent: 6107623 (2000-08-01), Bateman et al.
patent: 6124137 (2000-09-01), Hutchens et al.
patent: 6204500 (2001-03-01), Whitehouse et al.
patent: 6268144 (2001-07-01), Köster
patent: 6977143 (2005-12-01), Caulfield et al.
patent: 7087395 (2006-08-01), Garrity et al.
patent: 2004/0235193 (2004-11-01), Soldin
patent: 2006/0094125 (2006-05-01), Singh et al.
patent: 2006/0228808 (2006-10-01), Clarke et al.
patent: 2006/0228809 (2006-10-01), Clarke et al.
patent: WO 96/18618 (1996-06-01), None
patent: WO 2007/039193 (2007-04-01), None
patent: WO 2007/139956 (2007-12-01), None
Coldwell et al., “Mass Fragmentographic Assay for 25-Hydroxyvitamin D in Plasma Without Derivatization: Enhanced Sensitivity for Metabolites of Vitamins D2 and D3 After Pre-column Dehydration”, Journal of Mass Spectrometry, 30:348-356, 1995.
Maunsell et al., “Routine Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry Assay for Simultaneous Measurement of the 25-Hydroxy Metabolites of Vitamins D2 and D2”, Clinical Chemistry, 51:9 1683-1690, 2005.
Odrzywolska et al., “Convergent Synthesis, Chiral HPLC, and Vitamin D Receptor Affinity of Analogs of 1,25-Dihydroxycholecalciferol”, Chirality, 11:249-255, 1999.
Watson et al., “Analysis of Vitamin D and its Metabolites using Thermospray Liquid Chromatography/Mass Spectrometry”, Biomedical Chromatography, vol. 5, 153-160, 1991.
Yeung et al., “Characterization of the Metabolic Pathway of 1,25-Dihydroxy-16-Ene Vitamin D3 in Rat Kidney By On-Line High Performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry”, Biochemical Pharmacology, vol. 49, No. 8, pp. 1099-1110, 1995.
International Search Report for PCT Application PCT/US2006/12539.
Armas et. al., Vitamin D2 Is Much Less Effective than Vitamijn D3 in Humans, J. Clin. Endocrinol. Metab. 89:5387-5391 (2004).
Higashi T, et al., Simultaneous Determination of 25-Hydroxyvitamin D2and 25-Hydroxyvitamin D3in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry Employing Derivatization with a Cookson-Type Reagent, Biol Pharm Bull. 24(7):738-43, (2001).
Higashi T, et al., Characterization of urinary metabolites of vitamin D3in man under physiological conditions using liquid chromatography-tandem mass spectrometry, J Pharm Biomed Anal. 29(5):947-55 (2002).
Higashi T, et al., Characterization of new conjugated metabolites in bile of rats administered 24,25-dihydroxyvitamin D3and 25-hydroxyvitamin D3, Steroids. 65(5):281-94 (2000).
Kissmeyer and Sonne, Sensitive analysis of 1α,25-dihydroxyvitamin D3in biological fluids by liquid chromatography-tandem mass spectrometry, J Chromatogr A. 935(1-2):93-103 (2001).
Merchant and Weinberger, Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry,Electrophoresis21:1164-77 (2000).
Salm et al., The Quantification of Sirolimus by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Microparticle Enzyme Immunoassay in Renal Transplant Recipients,Clin. Therapeutics22 Supl. B:B71-B85 (2000).
Taylor et al., Simultaneous Quantification of Tacrolimus and Sirolimus in Human Blood, by High-Performance Liquid Chromatography—Tandem Mass Spectrometry,Therapeutic Drug Monitoring22:608-12 (2000).
Wright et al., Proteinchip® surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures,Prostate Cancer and Prostatic Diseases2:264-76 (1999).
Yeung B, et al.,Characterization of viatmin D3metabolites using continuous-flow fast atom bombardment tandem mass spectrometry and high performance liquid chromatography, Chromatogr. 645(1):115-23 (1993).
Zimmer et al., Comparison of turbulent-flow chromatography with automated solid-phase extraction in 96-well plates and liquid-liquid extraction used as plasma sample preparation techniques for liquid chromatography-tandem mass spectrometry,J. Chromatogr. A 854:23-35 (1999).
Vogeser et al., Candidate reference method for the quantification of circulating 25-Hydroxyvitamin D3by liquid chromatography-tandem mass spectrometry. Clinical Chemistry, 50(8): 1415-1417, 2004.
International Search Report for PCT Patent Application No. PCT/US2008/084709.
Bartolucci, et al., Liquid chromatography tandem mass spectrometric quantitation of sulfamethazine and its metabolites: direct analysis of swine urine by triple quadrupole and by ion trap mass spectrometry,Rapid Commun. Mass Spectrom, 14:967-73, 2000.
Busch, A Glossary for Mass Spectrometry. Mass Spectrometry, 17(65): 526-534, 2002.
Coldwell et al., Stable isotope-labeled vitamin D, metabolites and chemical analogs: synthesis and use in mass spectrometric studies. Steroids, 55: 418-432, 1990.
Guo et al., Steroid profiles using liquid chromatography-Tandem mass spectrometry with atmospheric pressure photoionization source. Arch Pathol Lab Med., 128: 469-475, 2004.
Jemal, High-throughput quantitative bioanalysis by LC/MS/MS. Biomedical Chromatography. 14:422-429, 2000.
Jones et al., Current understanding of the molecular actions of Vitamin D. Physiological Reviews, 78(4): 1193-1231, 1998.
Jones and Makin, Vitamin Ds: Metabolites and Analogs. Chapter 2 inModern Chromatographic Analysis of Vitamins, Third Edition, Revised and expanded, edited by Leenheer et al., New York: Marcel Dekker, Inc., 2002.
Miller and Portale, Genetic causes of rickets. Current Opinions in Pediatrics, 11:333-339, 1999.
Singh et al., C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. The Journal of Clinical Endocrinology & Metabolism, 91(8): 3055-3061, 2006.
Tsugawa et al., Determination of 25-hydroxyvitamin D in human plasma using high=performance liquid chromatography-tandem mass spectrometry. Anal. Chem., 77(9): 3001-3007, 2005.
Vieth, Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr, 69:842-856, 1999.
Vieth et al., Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more Vitamin D. The Journal of Clinical Endocrinology & Metabolism, 88(1): 185-191, 2003.
Wharton and Bishop, Rickets. The Lancet, 362: 1389-1400, 2003.
Letter from Vicki G. Norton, Ph.D. Partner, Duane Morris LLP, Sep. 4, 2008 (originally cited in an Information Disclosure Statement on Oct. 15, 2008 for U.S. Appl. No. 10/977,121).
Extended European Search Report for EPO Patent Application No. 06749272.8-2404.
Jones et al., Biological activity of 1,25-Dihydroxyvitamin D2in the Chick. Biochemistry, 15(3): 713-716, 1976.
Kissmeyer et al., Sensitive analysis of 1α, 25-dihydroxyvitamin D3in biological fluids by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 935(2001) 93-103.
Tsugawa et al., Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal. Chem., 77:3001-3007, 2005.
Watson and Setchell, Analysis of Vitamin D and its metabolites using thermospray liquid chromatography/Mass spectrometry. Biomedical Chromatography, 5:153-160, 1991.

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