Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-12-20
1998-12-08
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 913, 536 231, 536 243, 536 2433, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
058467238
ABSTRACT:
Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.
REFERENCES:
patent: 5583016 (1996-12-01), Villeponteau et al.
Albanell, Juan, et al. (1996) "Telomerase Activity Is Repressed During Differentiation of Maturation-sensitive but not Resistant Human Tumor Cell Lines", Cancer Research 56:1503-1508.
Avilion, Ariel A., et al. (1996) "Human Telomerase RNA and Telomerase Activity in Immortal Cell Lines and Tumor Tissues", Cancer Research 56:645-650.
Villeponteau, Bryant (1996) "The RNA components of human and mouse telomerases", seminars in Cell & Development Biology, 7:15-21.
Harley, Calvin B., et al. (1995) "Telomeres and telomerase in aging and cancer", Current Opinion in Genetics and Development, 5:249-255.
Feng, Junli, et al. (1995) "The RNA Component of Human Telomerase", Science, 269:1236-1241.
Kim, Nam W., et al. (1994) "Specific Association of Human Telomerase Activity with Immortal Cells and Cancer", Science, 266:2011-2015.
Blasco, Maria A., et al. (1995) "Functional Characterization and Developmental Regulation of Mouse Telomerase RNA", Science, 269:1267-1270.
Bodnar, Andrea G., et al., (1996) "Mechanism of Telomerase Induction during T Cell Activation", Experimental Cell Research, 228:58-68 Article No. 0299.
Khan, Islam et al., (1992), "Polymerase chain reaction assay or mRNA using 28S IRNA as internal standard", Neurosciences Letters, 147:114-117.
Kealey James T.
Kim Nam Woo
Pruzan Ronald
Weinrich Scott L.
Wu Fred
Geron Corporation
Jones W. Gary
Kaster Kevin R.
Parent Annette S.
Rees Dianne
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