Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-07-18
2010-12-21
Chunduru, Suryaprabha (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S024330
Reexamination Certificate
active
07855053
ABSTRACT:
The invention provides improved methods for detecting the presence of expanded CGG repeats in the fragile X mental retardation 1 (FMR1) gene and for quantifying the amount of protein produced by the gene.
REFERENCES:
patent: 6107025 (2000-08-01), Caskey et al.
patent: 7022486 (2006-04-01), Campbell
Strelnikov, V. et al. A simple multiplex FRAXA, FRAXE, and FRAXF PCR assay convenient for wide screening programs. Human Mutation, vol. 13, pp. 166-169, 1999.
Strelnikov, V., et al., “A simple multiplex FRAXA , FRAXE, and FRAXF PCR assay convenient for wide screening programs,” 1999,Human Mutation,vol. 13, pp. 166-169.
Tassone et al., “A Rapid Polymerase Chain Reaction-Based Screening Method for Identification of All Expanded Alleles of the Fragile X (FMR1) Gene in Newborn and High-Risk Populations,” Jan. 2008, Journal of Molecular Diagnosis, vol. 10, No. 1, pp. 43-49.
Warner et al., “A General Method for the Detection of Large CAG Repeat Expansions by Fluorescent PCR,” 1996, J. Med. Genet., Dec. 1996; 33: 1022-1026.
Hagerman Paul J.
Tassone Flora
Chunduru Suryaprabha
The Regents of the University of California
Townsend and Townsend / and Crew LLP
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