Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2003-07-02
2010-02-16
Crouch, Deborah (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S006120, C435S366000, C435S007200
Reexamination Certificate
active
07662625
ABSTRACT:
The present invention relates to methods for detecting the differentiation status of stem cells comprising detecting the expression of 5T4 antigen in said stem cells. The present invention also relates to methods for separating populations of undifferentiated or differentiated mammalian stem cells from a mixture of differentiated and undifferentiated stem cells through detection of 5T4 expression.
REFERENCES:
patent: 6312683 (2001-11-01), Carroll et al.
patent: 0336562 (1989-10-01), None
Southall, PJ et al. Br J Cancer 61(1):abstract 1990.
Boyle, JM et al. Hum Genet 94:455-458, 1990.
Ward, CM et al. Exp Cell Res, pp. 12-14, e-pub ahead of print, Apr. 14, 2006.
Ward, CM et al. J Cell Sci 116(22):4533-4542, 2003.
Southall, PJ et al. Br J Cancer 61:89-95, 1990.
Ward, CM et al. Exp Cell Res 293:229-238, 2004.
Stem Cells: Scientific Progress and Future Research Directions. Chapter 1 (pp. 1-4) and Chapter 4 (pp. 23-42). Department of Health and Human Services. Jun. 2001. <http://stemcells.nih.gov/info/scireport/2001report>.
Ali, A., et al. “The pattern of expression of the 5T4 oncofoetal antigen on normal, dysplastic and malignant oral mucosa”,Oral Oncology(2001) 37:57-64.
Awan, Abida, et al. “5T4 Interacts with TIP-2/GIPC, a PDZ Protein, with Implications for Metastasis”,Biochemical and Biophysical Research Communications(2002) 290:1030-1036.
Carsberg, Catherine J., et al. “Metastasis-Associated 5T4 Antigen Disrupts Cell-Cell Contacts and Induces Cellular Motility in Epithelial Cells”,Int. J. Cancer(1996) 68:84-92.
Carsberg, Catherine J., et al, “Metastasis-associated 5T4 oncofoetal antigen is concentrated at microvillus projections of the plasma membrane”,Journal of Cell Science(1995) 108:2905-2916.
Forsberg, G., et al. “Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen”,British Journal of Cancer(2001) 85(1):129-136.
Hole, N., et al. “A 72Kd trophoblast glycoprotein defined by a monoclonal antibody”,Br. J. Cancer(1988) 57:239-246.
Hole, N., et al. “Isolation and Characterization of 5T4, A Tumour-Associated Antigen”,Int. J. Cancer(1990) 45:179-184.
King, Karen W., et al. “Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues”,Biochimica et Biophysica Acta(1999) 1445:257-270.
Mulder, W. Mieke C., et al. “Low Intercellular Adhesion Molecule 1 and High 5T4 Expression on Tumor Cells Correlate with Reduced Disease-free Survival in Colorectal Carcinoma Patients”,Clinical Cancer Research(1997) 3:1923-1930.
Shaw, David M., et al. “Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen”Biochem J. (2002) 363:137-145.
Southall, P.J., et al. “Immunohistological distribution of 5T4 antigen in normal and malignant tissues”,Br. J. Cancer(1990) 61:89-95.
Starzynska T., et al. “Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma”,Br. J, Cancer(1994) 69:899-902.
Starzynska, T., et al. “The expression of 5T4 antigen in colorectal and gastric carcinoma”,Br. J. Cancer(1992) 68:867-869.
Starzynska, T., et al. “5T4 oncofetal in gastric carcinoma and its clinical significance”,European Journal of Gastroenterology&Hepatology(1998) 10(6):479-484.
Wrigley, E., et al. “5T4 oncofetal antigen expression in ovarian carcinoma”,Int. J. Gynecol Cancer(1995) 5:269-274.
Niwa, H., et al. “Quantitative expression of Oct.-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells”,nature genetics(2000) 24(4):372-376.
Chung, Young, et al. “Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres”,Nature(2006) 439:216-219.
Carroll Miles W.
Stern Peter L.
Ward Christopher M.
Cancer Research Technology Limited
Crouch Deborah
Marshall & Gerstein & Borun LLP
Noble Marcia S
LandOfFree
Methods for detecting the differentiation status of cells... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for detecting the differentiation status of cells..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for detecting the differentiation status of cells... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4152874