Methods for detecting parenchymal plaques in vivo

Details Methods for detecting parenchymal plaques in vivo Methods for detecting parenchymal plaques in vivo

2003-01-27

2008-05-13

Falk, Anne-Marie (Department: 1632)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S009100, C424S009300, C424S009341

Reexamination Certificate

active

07371365

ABSTRACT:
Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.

REFERENCES:
patent: 5231000 (1993-07-01), Majocha et al.
patent: 5262332 (1993-11-01), Selkoe
patent: 5670477 (1997-09-01), Poduslo et al.
patent: 5898094 (1999-04-01), Duff et al.
patent: 6821504 (2004-11-01), Wisniewski et al.
Muller-Gartner et al. (1998) Imaging techniques in the analysis of brain function and behaviour. Trends in Biotechnology 16: 122-130.
J.R. Ghilardi, et al., “Intra-arterial Infusion of [125I]A(beta)1-40 Labels Amyloid Deposits in the Aged Primate Brain In Vivo,” NeuroReport 7(15-17):2607-2611, 1996.
J.F. Poduslo and G.L. Curran, “Polyamine Modification Increases the Permeability of Proteins at the Blood-nerve and Blood-brain Barriers,” J. Neurochem. 66(4):1599-1609, 1996.
J.F. Poduslo, et al., “Molecular Targeting of Alzheimer's Amyloid Plaques for Contrast-enhanced Magnetic Resonance Imaging,” Neurobiol. Dis., pp. 1-15, 2002.
S.-P. Lee, et al., “Visualization of Beta-Amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease Using MR Microscopy Without Contrast Reagents,” Magnetic Res. Med. 52:538-544, 2004.
Holcomb et al., “Nature Med.”, 1998, 4:97-100.
Hsiao, et al., “Science”, 1996, 274:99-102.
Maggio et al., “Proc. Natl. Acad. Sci. USA”, 1992, 89(12):5462-5466.
Maggio et al., “Brain Pathol.”, 6:147-162. (1996) Brain amyloid—a physicochemical perspective.
Pallitto et al., “Biochemistry”, 1999, 38:3570-3578.
Poduslo, et al., “J. Neurobiol.”, 1999, 39:371-382.
Poduslo et al., “J. Neurochem.”, 1998, 71:1651-1660.
Poduslo and Curran, “J. Neurochem.”, 1996, 67:734-741.
Poduslo and Curran, “Molec. Brain Res.”, 1994, 23:157-162.
Poduslo and Curran, “Proc. Natl. Acad. Sci. USA”, 1992, 89:2218-2222.
Poduslo et al., “Proc. Natl. Acad. Sci. USA”, 1994, 91:5705-5709.
Reinholz et al., “Exp. Neurol.”, 1999, 159:191-203.
Reinholz et al., “Exp. Neurol.”, 1999, 159:204-216.
Saji, “Crit. Rev. Ther. Drug Carrier Syst.”, 1999, 16(2):209-244.
Selkoe, “Science”, 1997, 275:630-631.
Walker et al., “Acta Neuropathol.”, 1990, 80(4):381-387.
Wengenack et al., “Brain Res.”, 1997, 754:46-54.
Wengenack et al., “Brain Res.”, 1997, 767:128-135.

Affiliated with

Also associated with

Rating

Methods for detecting parenchymal plaques in vivo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for detecting parenchymal plaques in vivo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for detecting parenchymal plaques in vivo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3983682