Methods for detecting mutant p53

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 723, C12Q 168

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active

056208480

ABSTRACT:
A panel of probes detects and distinguishes between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells Each set of mutations gives rise to a phenotype that is different from that of wild-type p53 and of at least one other set of p53 mutations.

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Baker et al., Science, vol. 244, 1989, pp. 217-221.
Finlay et al., Mol. Cell. Biol., vol. 8, 1988, pp. 531-539.
Nigro et al., Nature, vol. 342, 1989, pp. 705-708.

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