Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-27
1998-01-27
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, 4352523, 435325, 4353201, 935 33, 935 34, 935 36, 935 70, C12Q 168
Patent
active
057120943
ABSTRACT:
The present invention provides DNA constructs that contain oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTN.sub.x AA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines, an operably linked promoter and operably linked heterologous gene. The present invention also provides host cells transfected with such DNA constructs, as well as methods for measuring the ability of compounds to act as agonists and antagonists of gene transcription utilizing these DNA constructs and transfected host cells.
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Pearse, R.; Feinman, R.; Shuai, K.; Darnell,
Chan Shin-Shay Tian
Lamb I. Peter
Seidel H. Martin
Elmer J. Scott
Ligand Pharmaceuticals Inc.
Mertz Prema
Ulm John
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