Methods for detecting cancer and monitoring cancer progression

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S007100

Reexamination Certificate

active

07393637

ABSTRACT:
Mutant BNIP3 plays a functionally important role in the development of solid tumors and in resistance to chemotherapy and radiation treatments. The invention relates to methods of detecting cancer, methods of monitoring the progression of cancer, methods of identifying patients with cancer that is resistant to chemotherapy or radiation treatments, and diagnostic kits for performing the methods of the invention.

REFERENCES:
patent: WO 00/55174 (2000-09-01), None
patent: WO 02/46465 (2002-06-01), None
Lee, H., and Paik, S. Regulation of BNIP3 in normal and cancer cells. 2006. Molecules and Cells, vol. 21 No. 1, pp. 1-6.
Zhou, J., Schmid, T., Schnitzer, S., and Brune, B. Tumor hypoxia and cancer prevention. 2006. Cancer Letters, vol. 237, pp. 10-21.
Burton, T.R., Henson, E.S., Baijal, P., Eisenstat, D.D., and Gibson, S.B. The pro-cell death BCL-2 family member BNIP3, is localized to the nucleus of human glial cells: implications for glioblastoma multiforme tumor cell survival under hypoxia. 2006, International Journal of Cancer, vol. 118, pp. 1660-1669.
Reiger, R., Michaelis, A, and Green, M.M. Glossary of genetics and cytogenetics. 1976. Springer-Verlag, pp. 17-18.
K. Guo et al, “Hypoxia induces the expressions of the pro-apoptotic gene BNIP3”, Cell Death and Differentiation, 2001, vol. 8, pp. 367-376.
Cizeau Jeannick et al, “TheC. elegansorthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism”, Oncogene, Nov. 16, 2000, vol. 19, No. 48, pp. 5453-5463.
Chen Gao et al, “Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins”, Journal of Biological Chemistry, Jan. 1, 1999, vol. 274, No. 1, pp. 7-10.
C. Vande Velde et al, “BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore”, Molecular and Cellular Biology, Aug. 2000, vol. 20, No. 15, pp. 5454-5468.
S. Kothari et al, “BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF”, Oncogene, Jul. 24, 2003, vol. 22, No. 30, pp. 4734-4744.
Eisenstat, Dr. David; NBTF Progress Report—“Oligo Fund”; Nov. 15, 2005, NBTF website, www.braintumor.org/research/past—recipients/2004—reports/Eisenstat—Oligo—detail.pdf.

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