Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2004-06-14
2008-07-01
Helms, Larry R. (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100
Reexamination Certificate
active
07393637
ABSTRACT:
Mutant BNIP3 plays a functionally important role in the development of solid tumors and in resistance to chemotherapy and radiation treatments. The invention relates to methods of detecting cancer, methods of monitoring the progression of cancer, methods of identifying patients with cancer that is resistant to chemotherapy or radiation treatments, and diagnostic kits for performing the methods of the invention.
REFERENCES:
patent: WO 00/55174 (2000-09-01), None
patent: WO 02/46465 (2002-06-01), None
Lee, H., and Paik, S. Regulation of BNIP3 in normal and cancer cells. 2006. Molecules and Cells, vol. 21 No. 1, pp. 1-6.
Zhou, J., Schmid, T., Schnitzer, S., and Brune, B. Tumor hypoxia and cancer prevention. 2006. Cancer Letters, vol. 237, pp. 10-21.
Burton, T.R., Henson, E.S., Baijal, P., Eisenstat, D.D., and Gibson, S.B. The pro-cell death BCL-2 family member BNIP3, is localized to the nucleus of human glial cells: implications for glioblastoma multiforme tumor cell survival under hypoxia. 2006, International Journal of Cancer, vol. 118, pp. 1660-1669.
Reiger, R., Michaelis, A, and Green, M.M. Glossary of genetics and cytogenetics. 1976. Springer-Verlag, pp. 17-18.
K. Guo et al, “Hypoxia induces the expressions of the pro-apoptotic gene BNIP3”, Cell Death and Differentiation, 2001, vol. 8, pp. 367-376.
Cizeau Jeannick et al, “TheC. elegansorthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism”, Oncogene, Nov. 16, 2000, vol. 19, No. 48, pp. 5453-5463.
Chen Gao et al, “Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins”, Journal of Biological Chemistry, Jan. 1, 1999, vol. 274, No. 1, pp. 7-10.
C. Vande Velde et al, “BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore”, Molecular and Cellular Biology, Aug. 2000, vol. 20, No. 15, pp. 5454-5468.
S. Kothari et al, “BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF”, Oncogene, Jul. 24, 2003, vol. 22, No. 30, pp. 4734-4744.
Eisenstat, Dr. David; NBTF Progress Report—“Oligo Fund”; Nov. 15, 2005, NBTF website, www.braintumor.org/research/past—recipients/2004—reports/Eisenstat—Oligo—detail.pdf.
Eisenstat David D.
Gibson Spencer B.
Bereskin & Parr
Gravelle Micheline
Gussow Anne M
Helms Larry R.
University of Manitoba
LandOfFree
Methods for detecting cancer and monitoring cancer progression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for detecting cancer and monitoring cancer progression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for detecting cancer and monitoring cancer progression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3965086