Methods for detecting and treating cancer

Details Methods for detecting and treating cancer Methods for detecting and treating cancer

2004-06-09

2010-11-16

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100

Reexamination Certificate

active

07833733

ABSTRACT:
Methods and kits for detecting cancer and monitoring cancer progression are described. The method involves analyzing a sample containing nucleic acids or proteins from a patient for decreased expression of endoglycan and/or increased expression of podocalyxin.

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patent: WO 02/079492 (2002-10-01), None
Tockman et al, Cancer Res., 1992, 52:2711s-2718s.
Schopperle, W.M. et al., Human Embryonal Carcinoma Tumor Antigen, Gp200/GCTM-2, is podocalyxin, Biochem. Biophys. Res. Comm., vol. 300, No. 2, Jan. 10, 2003, pp. 285-290.
Fieger, C.B. et al., Endoglycan, A member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x., J. Biol. Chem., vol. 278, No. 30, May 16, 2003.
Somasiri, A. et al., Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression, Cancer Res., vol. 64, Aug. 1, 2004, pp. 5068-5073.

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