Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Patent
1983-03-07
1985-12-10
Tokar, Michael J.
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
324300, G01R 3308
Patent
active
045582793
ABSTRACT:
A novel and improved method to detect indirectly a temperature of an object employing nuclear magnetic resonance techniques (NMR). The method involves obtaining an NMR spectrum to determine chemical shift, relaxation times, spin-spin couplings or quadrupole couplings for an element of a compound having at least one conformational isomer wherein the compound is influenced by a temperature of the object. Uniquely, the present invention may detect temperature in the body of an animal. Further, the present invention discloses a novel method to determine and monitor thermal physiological states in an animal as well as determine and monitor thermal states in an object. Because of the unique and advantageous non-invasive, non-destructive and non-ionizing properties, the present invention may be employed in an object or animal continuously. The present invention also provides for the thermal imaging, or NMR thermography, by one-, two-, or three-dimensional reconstruction techniques from chemical shift, relaxation times, (e.g., T.sub.1 or T.sub.2,) spin-spin couplings and quadrupole couplings for an element of a compound having at least one conformational isomer in an object or animal influenced by a temperature in the object or animal. The methods disclosed are applicable to inanimate and animate solids.
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Ackerman Jerome L.
Clark, Jr. Leland C.
Thomas Stephen R.
Children's Hospital Research Foundation
Tokar Michael J.
University of Cincinnati
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