Methods for detecting a polymorphism in the NFKB1 gene promoter

Details Methods for detecting a polymorphism in the NFKB1 gene promoter Methods for detecting a polymorphism in the NFKB1 gene promoter

2004-04-05

2011-12-06

Myers, Carla (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S006100, C435S006120, C435S006170, C435S091200, C536S024100, C536S024310, C536S024330

Reexamination Certificate

active

08071304

ABSTRACT:
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining similar relationships between specific pathologies and identified polymorphisms. A statistically significant risk of developing ulcerative colitis was shown to be correlated with the presence of an ATTG insertion/deletion in the NFKB1 promoter and is likely to apply also to a variety of other inflammatory diseases.

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